Equal randomization: Platinum_CT and PARPi more effective in the HRD+ biomarker signature (cfr scen 6)
| signature | var | Other | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.091, shape = 1.05 | scale = 0.091, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 10.8, median = 7.7 | mean = 10.8, median = 7.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.23, hr = 0.81 | af = 1.23, hr = 0.81 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.093, shape = 1.05 | scale = 0.093, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 10.5, median = 7.6 | mean = 10.5, median = 7.6 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.2, hr = 0.83 | af = 1.2, hr = 0.83 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.092, shape = 1.05 | scale = 0.092, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 10.7, median = 7.7 | mean = 10.7, median = 7.7 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.21, hr = 0.82 | af = 1.21, hr = 0.82 | |
| HRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.084, shape = 1.05 | scale = 0.084, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 11.7, median = 8.4 | mean = 11.7, median = 8.4 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.33, hr = 0.74 | af = 1.33, hr = 0.74 |
| subtype | var | Other | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 |
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The overall error was 0.268.
The corresponding errors separate for the different treatments were:
ARSi Taxane_CT Platinum_CT PARPi
0.026 0.030 0.134 0.106
The overall power was 0.832.
The corresponding power separate for the different treatments were:
ARSi Taxane_CT Platinum_CT PARPi
0.000 0.000 0.582 0.602
| signature | var | Control | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 0 | 2 | 13 | 19 |
| futility | 0 | 6 | 7 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 280 (245, 324) | 208 (148, 275) | 213 (144, 282) | 232 (159, 287) | 231 (171, 286) | |
| n_unique | 257 (224, 296) | 194 (136, 257) | 198 (134, 262) | 214 (145, 265) | 213 (155, 262) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 22 (15, 30) | 27 (5, 34) | 10 (4, 33) | 27 (12, 34) | |
| post_p | NA (NA, NA) | 0.4 (0.07, 0.86) | 0.43 (0.07, 0.84) | 1 (0.95, 1) | 1 (0.93, 1) | |
| rate | 0.111 (0.102, 0.122) | 0.113 (0.102, 0.126) | 0.113 (0.103, 0.126) | 0.082 (0.073, 0.091) | 0.081 (0.072, 0.092) | |
| TP53- & AR- | graduation | 0 | 12 | 12 | 140 | 119 |
| futility | 0 | 247 | 233 | 22 | 18 | |
| max_n | 0 | 16 | 12 | 18 | 14 | |
| n | 120 (95, 149) | 82 (27, 122) | 83 (27, 123) | 96 (29, 130) | 96 (32, 129) | |
| n_unique | 111 (87, 139) | 75 (25, 114) | 78 (26, 116) | 89 (27, 122) | 89 (29, 120) | |
| time_trial | 36 (36, 36) | 32 (11, 36) | 36 (11, 36) | 36 (12, 36) | 36 (13, 36) | |
| time_stop | NA (NA, NA) | 15 (9, 30) | 14 (10, 28) | 15 (10, 32) | 15 (10, 29) | |
| post_p | NA (NA, NA) | 0.38 (0.08, 0.83) | 0.39 (0.07, 0.85) | 0.95 (0.67, 1) | 0.94 (0.61, 1) | |
| rate | 0.111 (0.098, 0.129) | 0.115 (0.098, 0.143) | 0.114 (0.097, 0.144) | 0.084 (0.068, 0.101) | 0.084 (0.069, 0.102) | |
| TP53+ | graduation | 0 | 1 | 1 | 25 | 17 |
| futility | 0 | 74 | 74 | 3 | 2 | |
| max_n | 0 | 1 | 6 | 8 | 12 | |
| n | 119 (102, 142) | 105 (64, 125) | 104 (68, 129) | 104 (80, 127) | 105 (80, 129) | |
| n_unique | 109 (92, 130) | 97 (59, 115) | 96 (63, 119) | 95 (73, 117) | 97 (74, 118) | |
| time_trial | 36 (36, 36) | 36 (24, 36) | 36 (27, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 18 (8, 32) | 19 (9, 33) | 12 (8, 23) | 18 (10, 32) | |
| post_p | NA (NA, NA) | 0.41 (0.07, 0.83) | 0.42 (0.07, 0.8) | 0.96 (0.66, 1) | 0.96 (0.75, 1) | |
| rate | 0.111 (0.098, 0.129) | 0.113 (0.098, 0.133) | 0.114 (0.1, 0.133) | 0.084 (0.07, 0.099) | 0.082 (0.07, 0.097) | |
| HRD+ | graduation | 0 | 0 | 0 | 291 | 301 |
| futility | 0 | 214 | 197 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 84 (67, 105) | 56 (28, 88) | 59 (30, 91) | 59 (26, 88) | 56 (27, 87) | |
| n_unique | 78 (61, 98) | 51 (25, 80) | 54 (28, 85) | 53 (24, 81) | 52 (25, 79) | |
| time_trial | 36 (36, 36) | 36 (17, 36) | 36 (19, 36) | 33 (15, 36) | 32 (16, 36) | |
| time_stop | NA (NA, NA) | 21 (14, 32) | 22 (16, 32) | 24 (14, 34) | 23 (14, 33) | |
| post_p | NA (NA, NA) | 0.28 (0.05, 0.72) | 0.26 (0.05, 0.72) | 1 (1, 1) | 1 (1, 1) | |
| rate | 0.112 (0.095, 0.131) | 0.113 (0.094, 0.145) | 0.114 (0.095, 0.139) | 0.036 (0.028, 0.046) | 0.036 (0.028, 0.045) | |
| TEfus+ | graduation | 0 | 0 | 0 | 18 | 19 |
| futility | 0 | 65 | 67 | 0 | 1 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 104 (86, 125) | 79 (49, 104) | 80 (48, 109) | 86 (58, 108) | 83 (60, 108) | |
| n_unique | 95 (79, 113) | 72 (44, 97) | 74 (43, 100) | 78 (52, 99) | 76 (54, 98) | |
| time_trial | 36 (36, 36) | 36 (29, 36) | 36 (28, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 21 (12, 34) | 22 (13, 31) | 12 (10, 20) | 18 (11, 30) | |
| post_p | NA (NA, NA) | 0.43 (0.06, 0.82) | 0.38 (0.07, 0.82) | 0.98 (0.8, 1) | 0.99 (0.86, 1) | |
| rate | 0.112 (0.096, 0.127) | 0.113 (0.096, 0.135) | 0.113 (0.097, 0.132) | 0.074 (0.062, 0.091) | 0.073 (0.06, 0.087) |
| subtype | var | Control | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 259 | 248 | 170 | 144 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 16 | 12 | 18 | 14 | |
| n | 73 (56, 94) | 52 (17, 76) | 52 (17, 77) | 61 (20, 84) | 63 (20, 83) | |
| n_unique | 67 (51, 88) | 48 (16, 72) | 50 (16, 73) | 57 (18, 80) | 58 (19, 79) | |
| post_p | NA (NA, NA) | 0.46 (0.09, 0.84) | 0.46 (0.1, 0.86) | 0.52 (0.14, 0.89) | 0.51 (0.11, 0.89) | |
| rate | 0.112 (0.094, 0.133) | 0.116 (0.095, 0.147) | 0.113 (0.094, 0.149) | 0.112 (0.089, 0.135) | 0.112 (0.092, 0.135) | |
| —+ | graduation | 0 | 280 | 261 | 181 | 151 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 16 | 12 | 18 | 14 | |
| n | 15 (9, 22) | 9 (3, 17) | 9 (3, 18) | 12 (3, 19) | 12 (4, 20) | |
| n_unique | 14 (8, 20) | 8 (2, 16) | 8 (3, 17) | 11 (3, 17) | 11 (3, 18) | |
| post_p | NA (NA, NA) | 0.44 (0.2, 0.83) | 0.47 (0.19, 0.81) | 0.49 (0.16, 0.81) | 0.5 (0.17, 0.81) | |
| rate | 0.112 (0.077, 0.161) | 0.119 (0.074, 0.214) | 0.12 (0.075, 0.211) | 0.117 (0.072, 0.185) | 0.114 (0.074, 0.178) | |
| –+- | graduation | 0 | 75 | 77 | 39 | 37 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 6 | 8 | 12 | |
| n | 37 (29, 47) | 34 (21, 43) | 35 (23, 44) | 36 (24, 44) | 36 (27, 45) | |
| n_unique | 34 (26, 44) | 32 (20, 40) | 32 (22, 41) | 33 (22, 41) | 33 (25, 42) | |
| post_p | NA (NA, NA) | 0.48 (0.14, 0.88) | 0.48 (0.14, 0.82) | 0.48 (0.13, 0.85) | 0.51 (0.14, 0.89) | |
| rate | 0.112 (0.09, 0.141) | 0.113 (0.088, 0.148) | 0.115 (0.092, 0.147) | 0.114 (0.09, 0.144) | 0.113 (0.088, 0.145) | |
| –++ | graduation | 0 | 112 | 122 | 51 | 49 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 6 | 8 | 12 | |
| n | 25 (19, 34) | 23 (11, 31) | 23 (11, 30) | 24 (14, 33) | 24 (16, 32) | |
| n_unique | 23 (17, 31) | 21 (10, 29) | 21 (10, 29) | 22 (13, 30) | 22 (14, 29) | |
| post_p | NA (NA, NA) | 0.48 (0.17, 0.87) | 0.48 (0.16, 0.83) | 0.5 (0.14, 0.83) | 0.52 (0.18, 0.86) | |
| rate | 0.113 (0.085, 0.149) | 0.114 (0.084, 0.159) | 0.116 (0.085, 0.158) | 0.113 (0.083, 0.153) | 0.111 (0.084, 0.146) | |
| -+– | graduation | 0 | 345 | 336 | 357 | 359 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 16 | 12 | 16 | 12 | |
| n | 16 (10, 23) | 8 (3, 19) | 8 (3, 18) | 9 (3, 19) | 10 (3, 18) | |
| n_unique | 14 (9, 22) | 7 (2, 18) | 8 (2, 17) | 9 (3, 17) | 9 (3, 16) | |
| post_p | NA (NA, NA) | 0.3 (0.09, 0.59) | 0.31 (0.1, 0.61) | 0.92 (0.69, 0.99) | 0.92 (0.63, 1) | |
| rate | 0.11 (0.08, 0.163) | 0.12 (0.078, 0.216) | 0.119 (0.077, 0.204) | 0.036 (0.016, 0.065) | 0.037 (0.018, 0.066) | |
| -+-+ | graduation | 0 | 352 | 340 | 362 | 362 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 16 | 12 | 16 | 12 | |
| n | 16 (10, 23) | 8 (3, 18) | 8 (3, 18) | 10 (3, 19) | 9 (3, 18) | |
| n_unique | 15 (8, 21) | 7 (2, 16) | 7 (2, 17) | 9 (2, 18) | 8 (3, 17) | |
| post_p | NA (NA, NA) | 0.32 (0.12, 0.61) | 0.31 (0.1, 0.62) | 0.92 (0.67, 0.99) | 0.92 (0.66, 0.99) | |
| rate | 0.113 (0.074, 0.168) | 0.117 (0.075, 0.215) | 0.119 (0.077, 0.226) | 0.037 (0.019, 0.066) | 0.037 (0.017, 0.065) | |
| -++- | graduation | 0 | 240 | 233 | 307 | 311 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 6 | 7 | 12 | |
| n | 9 (5, 13) | 6 (2, 12) | 6 (2, 12) | 6 (2, 11) | 5 (2, 11) | |
| n_unique | 8 (4, 13) | 6 (2, 11) | 6 (2, 11) | 5 (2, 11) | 5 (1, 10) | |
| post_p | NA (NA, NA) | 0.35 (0.11, 0.59) | 0.34 (0.13, 0.63) | 0.83 (0.57, 0.97) | 0.82 (0.55, 0.96) | |
| rate | 0.116 (0.07, 0.197) | 0.122 (0.069, 0.253) | 0.118 (0.066, 0.221) | 0.037 (0.013, 0.077) | 0.037 (0.012, 0.08) | |
| -+++ | graduation | 0 | 254 | 253 | 313 | 315 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 6 | 7 | 12 | |
| n | 9 (5, 14) | 6 (2, 11) | 7 (2, 12) | 6 (2, 11) | 6 (2, 11) | |
| n_unique | 8 (4, 13) | 5 (2, 11) | 6 (2, 11) | 5 (1, 10) | 5 (2, 10) | |
| post_p | NA (NA, NA) | 0.34 (0.14, 0.63) | 0.34 (0.15, 0.6) | 0.8 (0.54, 0.95) | 0.81 (0.55, 0.97) | |
| rate | 0.114 (0.063, 0.191) | 0.121 (0.066, 0.256) | 0.117 (0.068, 0.229) | 0.039 (0.015, 0.078) | 0.036 (0.012, 0.076) | |
| +— | graduation | 0 | 6 | 9 | 13 | 19 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 12 (8, 17) | 12 (8, 17) | 12 (8, 16) | 12 (7, 17) | 12 (8, 17) | |
| n_unique | 10 (6, 15) | 11 (7, 16) | 11 (7, 15) | 11 (7, 15) | 11 (7, 15) | |
| post_p | NA (NA, NA) | 0.5 (0.17, 0.84) | 0.48 (0.17, 0.84) | 0.5 (0.18, 0.82) | 0.52 (0.19, 0.81) | |
| rate | 0.114 (0.074, 0.18) | 0.114 (0.072, 0.176) | 0.118 (0.076, 0.18) | 0.113 (0.075, 0.173) | 0.112 (0.077, 0.172) | |
| +–+ | graduation | 0 | 66 | 69 | 27 | 32 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 10 (6, 14) | 9 (5, 14) | 9 (5, 14) | 9 (5, 13) | 9 (5, 14) | |
| n_unique | 9 (5, 13) | 8 (5, 13) | 8 (4, 13) | 9 (5, 13) | 8 (4, 13) | |
| post_p | NA (NA, NA) | 0.48 (0.2, 0.81) | 0.48 (0.19, 0.84) | 0.48 (0.19, 0.8) | 0.5 (0.19, 0.81) | |
| rate | 0.116 (0.069, 0.189) | 0.117 (0.072, 0.195) | 0.119 (0.068, 0.205) | 0.119 (0.074, 0.186) | 0.112 (0.071, 0.195) | |
| +-+- | graduation | 0 | 75 | 77 | 39 | 37 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 6 | 8 | 12 | |
| n | 10 (6, 15) | 9 (4, 14) | 9 (5, 13) | 10 (5, 14) | 10 (5, 14) | |
| n_unique | 9 (5, 13) | 8 (4, 12) | 8 (4, 12) | 9 (4, 13) | 9 (5, 13) | |
| post_p | NA (NA, NA) | 0.47 (0.17, 0.79) | 0.5 (0.18, 0.78) | 0.49 (0.2, 0.82) | 0.5 (0.21, 0.83) | |
| rate | 0.112 (0.07, 0.184) | 0.12 (0.072, 0.198) | 0.114 (0.075, 0.195) | 0.115 (0.069, 0.18) | 0.114 (0.072, 0.182) | |
| +-++ | graduation | 0 | 112 | 122 | 51 | 49 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 6 | 8 | 12 | |
| n | 10 (6, 15) | 9 (4, 14) | 9 (4, 14) | 9 (5, 14) | 9 (5, 15) | |
| n_unique | 9 (6, 14) | 8 (3, 13) | 8 (3, 13) | 8 (4, 13) | 9 (4, 13) | |
| post_p | NA (NA, NA) | 0.47 (0.16, 0.8) | 0.5 (0.19, 0.81) | 0.49 (0.19, 0.8) | 0.53 (0.21, 0.82) | |
| rate | 0.114 (0.069, 0.185) | 0.12 (0.073, 0.212) | 0.113 (0.072, 0.218) | 0.117 (0.069, 0.194) | 0.108 (0.07, 0.18) | |
| ++– | graduation | 0 | 215 | 199 | 299 | 308 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 8 (5, 13) | 7 (2, 11) | 7 (3, 12) | 6 (2, 11) | 6 (2, 11) | |
| n_unique | 8 (5, 12) | 6 (2, 10) | 6 (2, 11) | 5 (2, 10) | 5 (2, 10) | |
| post_p | NA (NA, NA) | 0.33 (0.13, 0.59) | 0.34 (0.14, 0.59) | 0.82 (0.55, 0.97) | 0.82 (0.58, 0.97) | |
| rate | 0.115 (0.068, 0.191) | 0.12 (0.069, 0.217) | 0.119 (0.063, 0.252) | 0.037 (0.013, 0.08) | 0.035 (0.013, 0.077) | |
| ++-+ | graduation | 0 | 232 | 226 | 305 | 313 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 9 (5, 13) | 6 (2, 11) | 7 (2, 12) | 6 (2, 11) | 5 (2, 10) | |
| n_unique | 8 (4, 12) | 5 (2, 10) | 6 (2, 11) | 5 (2, 10) | 5 (2, 10) | |
| post_p | NA (NA, NA) | 0.33 (0.12, 0.61) | 0.34 (0.11, 0.6) | 0.8 (0.55, 0.97) | 0.81 (0.57, 0.96) | |
| rate | 0.112 (0.068, 0.192) | 0.124 (0.07, 0.265) | 0.115 (0.068, 0.24) | 0.037 (0.01, 0.073) | 0.035 (0.012, 0.072) | |
| +++- | graduation | 0 | 240 | 233 | 307 | 311 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 6 | 7 | 12 | |
| n | 9 (5, 13) | 6 (2, 11) | 7 (2, 12) | 6 (2, 11) | 6 (2, 11) | |
| n_unique | 8 (4, 13) | 6 (2, 10) | 6 (2, 11) | 5 (2, 10) | 5 (2, 10) | |
| post_p | NA (NA, NA) | 0.35 (0.15, 0.63) | 0.35 (0.12, 0.6) | 0.82 (0.57, 0.96) | 0.83 (0.53, 0.96) | |
| rate | 0.119 (0.069, 0.197) | 0.112 (0.065, 0.244) | 0.116 (0.068, 0.225) | 0.036 (0.014, 0.076) | 0.037 (0.014, 0.079) | |
| ++++ | graduation | 0 | 254 | 253 | 313 | 315 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 1 | 6 | 7 | 12 | |
| n | 9 (5, 14) | 6 (2, 12) | 6 (2, 12) | 6 (2, 11) | 6 (2, 11) | |
| n_unique | 8 (4, 13) | 5 (2, 11) | 6 (2, 11) | 5 (1, 10) | 5 (2, 10) | |
| post_p | NA (NA, NA) | 0.35 (0.14, 0.6) | 0.32 (0.13, 0.59) | 0.81 (0.54, 0.96) | 0.82 (0.55, 0.97) | |
| rate | 0.114 (0.066, 0.19) | 0.121 (0.066, 0.235) | 0.123 (0.075, 0.244) | 0.038 (0.014, 0.075) | 0.036 (0.013, 0.074) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|
| all | count | 2 | 13 | 19 | |
| time_stop | 5 (5, 5) | 10 (4, 33) | 27 (12, 34) | ||
| n_trt | 32 (28, 36) | 67 (25, 150) | 155 (87, 225) | ||
| n_control | 34 (24, 44) | 70 (31, 265) | 203 (82, 275) | ||
| post_p | 0.9 (0.88, 0.92) | 1 (0.92, 1) | 1 (0.97, 1) | ||
| order | 1 (1, 1) | 1 (1, 5) | 3 (1, 5) | ||
| TP53- & AR- | count | 12 | 12 | 140 | 119 |
| time_stop | 10 (8, 14) | 14 (10, 16) | 16 (10, 33) | 17 (10, 30) | |
| n_trt | 26 (25, 31) | 32 (25, 42) | 44 (26, 95) | 41 (26, 94) | |
| n_control | 24 (22, 38) | 38 (30, 48) | 47 (25, 104) | 48 (26, 97) | |
| post_p | 0.9 (0.86, 0.97) | 0.94 (0.89, 0.98) | 0.97 (0.89, 1) | 0.96 (0.89, 1) | |
| order | 1 (1, 1.9) | 1 (1, 2) | 1 (1, 3) | 1 (1, 3) | |
| TP53+ | count | 1 | 1 | 25 | 17 |
| time_stop | 9 (9, 9) | 8 (8, 8) | 11 (8, 24) | 21 (10, 32) | |
| n_trt | 32 (32, 32) | 25 (25, 25) | 34 (25, 60) | 64 (27, 103) | |
| n_control | 23 (23, 23) | 15 (15, 15) | 32 (22, 72) | 71 (33, 113) | |
| post_p | 0.92 (0.92, 0.92) | 0.99 (0.99, 0.99) | 0.98 (0.9, 1) | 1 (0.95, 1) | |
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 3) | 2 (1, 3.4) | |
| HRD+ | count | 291 | 301 | ||
| time_stop | 24 (14, 34) | 23 (14, 33) | |||
| n_trt | 42 (26, 76) | 43 (26, 74) | |||
| n_control | 51 (25, 82) | 47 (25, 79) | |||
| post_p | 1 (0.98, 1) | 1 (0.99, 1) | |||
| order | 2 (1, 3) | 2 (1, 3) | |||
| TEfus+ | count | 18 | 19 | ||
| time_stop | 12 (10, 20) | 20 (11, 30) | |||
| n_trt | 30 (26, 51) | 43 (25, 72) | |||
| n_control | 30 (24, 52) | 49 (25, 85) | |||
| post_p | 0.99 (0.91, 1) | 0.99 (0.97, 1) | |||
| order | 1.5 (1, 4) | 2 (1, 4) |
| signature | var | ARSi | Taxane_CT | Platinum_CT | PARPi |
|---|---|---|---|---|---|
| all | count | 6 | 7 | ||
| time_stop | 22 (15, 30) | 31 (23, 34) | |||
| n_trt | 110 (77, 188) | 132 (98, 188) | |||
| n_control | 157 (110, 220) | 227 (180, 265) | |||
| post_p | 0.01 (0.01, 0.2) | 0.01 (0, 0.1) | |||
| order | 3.5 (2.5, 5) | 5 (3.6, 6) | |||
| TP53- & AR- | count | 247 | 233 | 22 | 18 |
| time_stop | 16 (9, 30) | 14 (10, 28) | 12 (8, 17) | 12 (9, 19) | |
| n_trt | 40 (26, 86) | 37 (26, 80) | 30 (25, 40) | 29 (26, 53) | |
| n_control | 44 (23, 87) | 38 (23, 86) | 32 (17, 43) | 34 (20, 54) | |
| post_p | 0.18 (0.05, 0.28) | 0.16 (0.04, 0.27) | 0.13 (0.05, 0.23) | 0.17 (0.05, 0.26) | |
| order | 1 (1, 3) | 1 (1, 3) | 1 (1, 2) | 1 (1, 2) | |
| TP53+ | count | 74 | 74 | 3 | 2 |
| time_stop | 18 (8, 32) | 20 (10, 33) | 12 (9, 17) | 12 (7, 16) | |
| n_trt | 54 (26, 87) | 58 (27, 101) | 28 (27, 42) | 34 (27, 41) | |
| n_control | 54 (24, 102) | 56 (29, 107) | 43 (26, 61) | 36 (21, 52) | |
| post_p | 0.08 (0.02, 0.24) | 0.08 (0.01, 0.23) | 0.06 (0.02, 0.13) | 0.13 (0.13, 0.14) | |
| order | 2 (1, 4.7) | 2 (1, 4) | 1 (1, 1.8) | 1 (1, 1) | |
| HRD+ | count | 214 | 197 | ||
| time_stop | 21 (14, 32) | 22 (16, 32) | |||
| n_trt | 36 (26, 60) | 39 (27, 68) | |||
| n_control | 43 (24, 70) | 47 (28, 77) | |||
| post_p | 0.1 (0.01, 0.24) | 0.09 (0.01, 0.21) | |||
| order | 2 (1, 4) | 2 (1, 4) | |||
| TEfus+ | count | 65 | 67 | 1 | |
| time_stop | 21 (12, 34) | 22 (13, 31) | 15 (15, 15) | ||
| n_trt | 44 (27, 77) | 49 (29, 76) | 25 (25, 25) | ||
| n_control | 53 (25, 99) | 60 (31, 97) | 37 (37, 37) | ||
| post_p | 0.08 (0.01, 0.19) | 0.07 (0.01, 0.21) | 0.02 (0.02, 0.02) | ||
| order | 3 (1, 4.6) | 3 (1, 5) | 1 (1, 1) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Taxane_CT | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| time | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | 5 (5, 5) | ||
| n | 12 (10, 13) | 0 (0, 1) | 5 (3, 7) | 2 (1, 4) | 1 (0, 2) | 1 (0, 2) | 0 (0, 0) | 1 (0, 2) | 2 (0, 3) | 2 (1, 3) | 2 (2, 2) | 0 (0, 1) | 2 (2, 2) | 0 (0, 1) | 1 (0, 2) | 0 (0, 0) | ||
| post_p | 0.6 (0.58, 0.62) | NA (NA, NA) | 0.57 (0.56, 0.57) | 0.57 (0.56, 0.59) | 0.6 (0.6, 0.6) | 0.53 (0.53, 0.53) | NA (NA, NA) | 0.5 (0.5, 0.5) | 0.62 (0.62, 0.62) | 0.53 (0.52, 0.53) | 0.51 (0.51, 0.51) | 0.53 (0.53, 0.53) | 0.57 (0.57, 0.57) | 0.54 (0.54, 0.54) | 0.58 (0.58, 0.58) | NA (NA, NA) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.044 (0.009, 0.078) | 0 (0, 0) | 0.045 (0.009, 0.08) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.177 (0.177, 0.177) | 0 (0, 0) | 0.066 (0.013, 0.119) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | ||
| Platinum_CT | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | |
| time | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | 10 (4, 33) | ||
| n | 14 (6, 39) | 4 (0, 10) | 13 (4, 29) | 8 (1, 18) | 3 (2, 8) | 3 (1, 8) | 2 (1, 7) | 2 (1, 3) | 4 (1, 13) | 3 (1, 7) | 3 (0, 7) | 3 (1, 9) | 2 (0, 5) | 2 (1, 4) | 2 (0, 8) | 3 (0, 5) | ||
| post_p | 0.7 (0.52, 0.93) | 0.59 (0.53, 0.8) | 0.59 (0.53, 0.76) | 0.64 (0.51, 0.79) | 0.59 (0.52, 0.87) | 0.69 (0.52, 0.9) | 0.59 (0.53, 0.74) | 0.55 (0.51, 0.82) | 0.62 (0.52, 0.75) | 0.65 (0.51, 0.76) | 0.56 (0.52, 0.83) | 0.56 (0.52, 0.75) | 0.53 (0.51, 0.68) | 0.64 (0.52, 0.74) | 0.62 (0.52, 0.81) | 0.63 (0.54, 0.91) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.087 (0.035, 0.127) | 0.077 (0, 0.106) | 0.095 (0, 0.123) | 0.08 (0, 0.123) | 0.007 (0, 0.069) | 0.02 (0, 0.045) | 0 (0, 0.059) | 0 (0, 0.074) | 0.062 (0, 0.126) | 0.031 (0, 0.114) | 0.052 (0, 0.13) | 0.07 (0, 0.129) | 0.038 (0, 0.073) | 0 (0, 0.057) | 0 (0, 0.058) | 0.014 (0, 0.06) | ||
| PARPi | count | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | |
| time | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | 27 (12, 34) | ||
| n | 36 (16, 59) | 5 (2, 10) | 26 (12, 32) | 14 (7, 23) | 6 (2, 14) | 6 (2, 12) | 3 (0, 8) | 3 (1, 6) | 9 (3, 12) | 5 (0, 8) | 9 (2, 14) | 6 (0, 9) | 3 (1, 8) | 3 (1, 6) | 5 (1, 9) | 4 (2, 8) | ||
| post_p | 0.65 (0.54, 0.87) | 0.72 (0.54, 0.8) | 0.62 (0.55, 0.86) | 0.69 (0.55, 0.88) | 0.88 (0.55, 0.97) | 0.86 (0.62, 0.99) | 0.76 (0.55, 0.88) | 0.65 (0.56, 0.9) | 0.6 (0.51, 0.85) | 0.62 (0.53, 0.82) | 0.58 (0.51, 0.67) | 0.64 (0.54, 0.8) | 0.74 (0.56, 0.91) | 0.65 (0.58, 0.83) | 0.72 (0.57, 0.93) | 0.75 (0.58, 0.92) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.103 (0.072, 0.122) | 0.079 (0.048, 0.171) | 0.093 (0.072, 0.118) | 0.095 (0.078, 0.11) | 0.042 (0, 0.059) | 0.026 (0, 0.046) | 0.04 (0, 0.052) | 0.042 (0, 0.066) | 0.093 (0.048, 0.13) | 0.094 (0.072, 0.122) | 0.106 (0.063, 0.132) | 0.086 (0.055, 0.119) | 0.033 (0, 0.061) | 0.025 (0, 0.05) | 0.037 (0, 0.065) | 0.018 (0, 0.048) | ||
| TP53- & AR- | ARSi | count | 12 | 12 | 12 | 12 | ||||||||||||
| time | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | ||||||||||||||
| n | 19 (15, 22) | 3 (2, 5) | 2 (1, 4) | 4 (1, 5) | ||||||||||||||
| post_p | 0.82 (0.75, 0.93) | 0.59 (0.53, 0.72) | 0.54 (0.52, 0.63) | 0.58 (0.52, 0.69) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.079 (0.055, 0.097) | 0 (0, 0.174) | 0 (0, 0.043) | 0.056 (0, 0.113) | ||||||||||||||
| Taxane_CT | count | 12 | 12 | 12 | 12 | |||||||||||||
| time | 14 (10, 16) | 14 (10, 16) | 14 (10, 16) | 14 (10, 16) | ||||||||||||||
| n | 20 (18, 26) | 4 (1, 6) | 4 (2, 9) | 4 (1, 6) | ||||||||||||||
| post_p | 0.85 (0.76, 0.97) | 0.58 (0.52, 0.75) | 0.56 (0.5, 0.82) | 0.56 (0.54, 0.75) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.071 (0.044, 0.101) | 0.081 (0, 0.112) | 0.05 (0, 0.134) | 0.059 (0, 0.089) | ||||||||||||||
| Platinum_CT | count | 140 | 140 | 140 | 140 | |||||||||||||
| time | 16 (10, 33) | 16 (10, 33) | 16 (10, 33) | 16 (10, 33) | ||||||||||||||
| n | 28 (17, 59) | 5 (2, 13) | 5 (2, 15) | 5 (2, 12) | ||||||||||||||
| post_p | 0.78 (0.71, 0.93) | 0.68 (0.52, 0.81) | 0.73 (0.55, 0.96) | 0.73 (0.55, 0.96) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.086 (0.052, 0.107) | 0.071 (0, 0.127) | 0.025 (0, 0.056) | 0.02 (0, 0.054) | ||||||||||||||
| PARPi | count | 119 | 119 | 119 | 119 | |||||||||||||
| time | 17 (10, 30) | 17 (10, 30) | 17 (10, 30) | 17 (10, 30) | ||||||||||||||
| n | 27 (16, 57) | 5 (2, 12) | 5 (2, 14) | 5 (2, 13) | ||||||||||||||
| post_p | 0.75 (0.71, 0.88) | 0.66 (0.54, 0.84) | 0.75 (0.54, 0.95) | 0.72 (0.53, 0.94) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.092 (0.061, 0.112) | 0.076 (0, 0.143) | 0.027 (0, 0.063) | 0.027 (0, 0.066) | ||||||||||||||
| TP53+ | ARSi | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | ||||||||||
| n | 5 (5, 5) | 8 (8, 8) | 3 (3, 3) | 5 (5, 5) | 1 (1, 1) | 4 (4, 4) | 3 (3, 3) | 3 (3, 3) | ||||||||||
| post_p | 0.5 (0.5, 0.5) | 0.88 (0.88, 0.88) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.51 (0.51, 0.51) | 0.64 (0.64, 0.64) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.098 (0.098, 0.098) | 0.068 (0.068, 0.068) | 0.107 (0.107, 0.107) | 0.044 (0.044, 0.044) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.182 (0.182, 0.182) | ||||||||||
| Taxane_CT | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | ||||||||||
| n | 11 (11, 11) | 4 (4, 4) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 3 (3, 3) | ||||||||||
| post_p | 0.89 (0.89, 0.89) | 0.65 (0.65, 0.65) | 0.6 (0.6, 0.6) | NA (NA, NA) | NA (NA, NA) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.56 (0.56, 0.56) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | ||||||||||
| Platinum_CT | count | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | |||||||||
| time | 11 (8, 24) | 11 (8, 24) | 11 (8, 24) | 11 (8, 24) | 11 (8, 24) | 11 (8, 24) | 11 (8, 24) | 11 (8, 24) | ||||||||||
| n | 13 (8, 27) | 8 (4, 16) | 3 (1, 4) | 2 (0, 5) | 3 (0, 5) | 2 (1, 5) | 2 (0, 4) | 2 (0, 4) | ||||||||||
| post_p | 0.76 (0.71, 0.87) | 0.73 (0.55, 0.84) | 0.61 (0.53, 0.75) | 0.63 (0.53, 0.73) | 0.62 (0.52, 0.83) | 0.58 (0.51, 0.71) | 0.56 (0.52, 0.65) | 0.54 (0.51, 0.85) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.066 (0.023, 0.106) | 0.073 (0.035, 0.099) | 0 (0, 0.062) | 0 (0, 0.071) | 0.018 (0, 0.096) | 0.067 (0, 0.112) | 0 (0, 0.071) | 0 (0, 0.078) | ||||||||||
| PARPi | count | 17 | 17 | 17 | 17 | 17 | 17 | 17 | 17 | |||||||||
| time | 21 (10, 32) | 21 (10, 32) | 21 (10, 32) | 21 (10, 32) | 21 (10, 32) | 21 (10, 32) | 21 (10, 32) | 21 (10, 32) | ||||||||||
| n | 23 (10, 32) | 13 (3, 25) | 4 (1, 11) | 4 (2, 8) | 4 (1, 10) | 4 (1, 8) | 3 (1, 9) | 3 (1, 10) | ||||||||||
| post_p | 0.8 (0.72, 0.87) | 0.73 (0.62, 0.89) | 0.73 (0.55, 0.81) | 0.7 (0.51, 0.85) | 0.6 (0.54, 0.84) | 0.66 (0.53, 0.78) | 0.6 (0.51, 0.92) | 0.71 (0.59, 0.97) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.088 (0.047, 0.104) | 0.096 (0.047, 0.113) | 0.029 (0, 0.05) | 0.02 (0, 0.077) | 0.07 (0, 0.108) | 0.064 (0, 0.113) | 0.023 (0, 0.061) | 0.014 (0, 0.054) | ||||||||||
| HRD+ | Platinum_CT | count | 291 | 291 | 291 | 291 | 291 | 291 | 291 | 291 | ||||||||
| time | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | ||||||||||
| n | 7 (3, 16) | 8 (3, 17) | 4 (2, 10) | 4 (1, 10) | 5 (2, 10) | 4 (2, 9) | 4 (2, 9) | 4 (2, 10) | ||||||||||
| post_p | 0.8 (0.58, 0.98) | 0.8 (0.59, 0.97) | 0.72 (0.55, 0.91) | 0.7 (0.53, 0.9) | 0.72 (0.53, 0.91) | 0.7 (0.53, 0.9) | 0.72 (0.53, 0.91) | 0.71 (0.53, 0.92) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.031 (0, 0.063) | 0.034 (0, 0.062) | 0.03 (0, 0.071) | 0.03 (0, 0.064) | 0.03 (0, 0.074) | 0.03 (0, 0.071) | 0.028 (0, 0.069) | 0.029 (0, 0.073) | ||||||||||
| PARPi | count | 301 | 301 | 301 | 301 | 301 | 301 | 301 | 301 | |||||||||
| time | 23 (14, 33) | 23 (14, 33) | 23 (14, 33) | 23 (14, 33) | 23 (14, 33) | 23 (14, 33) | 23 (14, 33) | 23 (14, 33) | ||||||||||
| n | 8 (3, 15) | 8 (3, 15) | 4 (1, 10) | 5 (2, 9) | 5 (2, 9) | 4 (2, 9) | 5 (2, 9) | 4 (2, 9) | ||||||||||
| post_p | 0.82 (0.59, 0.96) | 0.8 (0.6, 0.97) | 0.7 (0.54, 0.9) | 0.7 (0.54, 0.92) | 0.73 (0.54, 0.9) | 0.72 (0.54, 0.89) | 0.72 (0.54, 0.9) | 0.71 (0.53, 0.9) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.032 (0, 0.058) | 0.033 (0, 0.058) | 0.031 (0, 0.066) | 0.029 (0, 0.069) | 0.029 (0, 0.065) | 0.029 (0, 0.071) | 0.029 (0, 0.064) | 0.027 (0, 0.071) | ||||||||||
| TEfus+ | Platinum_CT | count | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | ||||||||
| time | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | 12 (10, 20) | ||||||||||
| n | 4 (3, 9) | 9 (5, 14) | 4 (2, 8) | 2 (1, 5) | 3 (2, 7) | 3 (0, 6) | 3 (0, 4) | 3 (1, 5) | ||||||||||
| post_p | 0.63 (0.53, 0.74) | 0.77 (0.63, 0.81) | 0.64 (0.55, 0.8) | 0.58 (0.53, 0.65) | 0.63 (0.53, 0.79) | 0.62 (0.55, 0.79) | 0.61 (0.51, 0.79) | 0.58 (0.52, 0.79) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.072 (0, 0.128) | 0.061 (0.035, 0.104) | 0 (0, 0.049) | 0 (0, 0.071) | 0.076 (0, 0.133) | 0.068 (0, 0.135) | 0 (0, 0.067) | 0 (0, 0.069) | ||||||||||
| PARPi | count | 19 | 19 | 19 | 19 | 19 | 19 | 19 | 19 | |||||||||
| time | 20 (11, 30) | 20 (11, 30) | 20 (11, 30) | 20 (11, 30) | 20 (11, 30) | 20 (11, 30) | 20 (11, 30) | 20 (11, 30) | ||||||||||
| n | 4 (3, 11) | 15 (5, 23) | 6 (3, 15) | 3 (1, 6) | 3 (2, 6) | 5 (1, 8) | 3 (2, 5) | 2 (1, 8) | ||||||||||
| post_p | 0.73 (0.55, 0.87) | 0.81 (0.67, 0.9) | 0.78 (0.58, 0.92) | 0.67 (0.54, 0.92) | 0.57 (0.52, 0.74) | 0.6 (0.51, 0.83) | 0.65 (0.55, 0.83) | 0.58 (0.53, 0.87) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.077 (0.026, 0.117) | 0.074 (0.048, 0.099) | 0.027 (0, 0.045) | 0.011 (0, 0.038) | 0.096 (0.038, 0.134) | 0.09 (0, 0.125) | 0 (0, 0.039) | 0.005 (0, 0.07) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | ARSi | count | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| time | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | 22 (15, 30) | ||
| n | 26 (20, 46) | 4 (0, 10) | 20 (5, 30) | 10 (5, 17) | 6 (4, 8) | 6 (2, 12) | 4 (2, 8) | 4 (2, 10) | 8 (2, 11) | 6 (1, 10) | 6 (2, 8) | 4 (1, 6) | 4 (2, 5) | 4 (2, 7) | 4 (2, 8) | 4 (1, 8) | ||
| post_p | 0.32 (0.18, 0.45) | 0.41 (0.39, 0.47) | 0.3 (0.1, 0.38) | 0.34 (0.24, 0.42) | 0.37 (0.08, 0.44) | 0.44 (0.33, 0.48) | 0.3 (0.13, 0.38) | 0.38 (0.25, 0.44) | 0.43 (0.34, 0.46) | 0.39 (0.32, 0.42) | 0.44 (0.25, 0.46) | 0.34 (0.26, 0.4) | 0.3 (0.24, 0.38) | 0.35 (0.18, 0.45) | 0.24 (0.18, 0.45) | 0.34 (0.15, 0.43) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.119 (0.108, 0.137) | 0.161 (0.102, 0.242) | 0.139 (0.128, 0.22) | 0.139 (0.114, 0.169) | 0.153 (0.088, 0.215) | 0.1 (0.067, 0.607) | 0.152 (0.115, 0.331) | 0.138 (0.094, 0.209) | 0.138 (0.107, 0.184) | 0.152 (0.097, 0.212) | 0.127 (0.11, 0.184) | 0.195 (0.141, 0.592) | 0.178 (0.123, 0.207) | 0.143 (0.091, 0.541) | 0.204 (0.07, 1.603) | 0.111 (0.102, 0.353) | ||
| Taxane_CT | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | |
| time | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | 31 (23, 34) | ||
| n | 23 (21, 48) | 4 (2, 11) | 29 (11, 35) | 10 (5, 19) | 5 (3, 10) | 6 (2, 11) | 2 (2, 8) | 3 (1, 8) | 7 (3, 11) | 8 (4, 8) | 7 (4, 11) | 4 (1, 6) | 5 (3, 10) | 6 (3, 10) | 4 (1, 10) | 3 (1, 6) | ||
| post_p | 0.32 (0.09, 0.49) | 0.4 (0.34, 0.46) | 0.3 (0.18, 0.39) | 0.35 (0.2, 0.44) | 0.17 (0.09, 0.39) | 0.3 (0.22, 0.43) | 0.32 (0.23, 0.39) | 0.37 (0.17, 0.41) | 0.32 (0.18, 0.46) | 0.24 (0.15, 0.39) | 0.29 (0.16, 0.43) | 0.38 (0.2, 0.49) | 0.41 (0.14, 0.49) | 0.35 (0.3, 0.45) | 0.36 (0.28, 0.47) | 0.44 (0.29, 0.47) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.131 (0.112, 0.164) | 0.146 (0.09, 0.366) | 0.139 (0.119, 0.151) | 0.154 (0.109, 0.179) | 0.162 (0.1, 0.186) | 0.122 (0.077, 0.216) | 0.181 (0.136, 0.543) | 0.157 (0.106, 0.496) | 0.155 (0.107, 0.468) | 0.169 (0.113, 0.347) | 0.128 (0.084, 0.154) | 0.26 (0.118, 0.445) | 0.113 (0.082, 0.301) | 0.099 (0.084, 0.21) | 0.133 (0.095, 1.155) | 0.094 (0.077, 0.148) | ||
| TP53- & AR- | ARSi | count | 247 | 247 | 247 | 247 | ||||||||||||
| time | 16 (9, 30) | 16 (9, 30) | 16 (9, 30) | 16 (9, 30) | ||||||||||||||
| n | 24 (15, 53) | 5 (2, 12) | 5 (2, 11) | 5 (2, 11) | ||||||||||||||
| post_p | 0.33 (0.13, 0.47) | 0.42 (0.22, 0.49) | 0.37 (0.15, 0.47) | 0.38 (0.15, 0.47) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.126 (0.103, 0.171) | 0.146 (0.094, 0.282) | 0.13 (0.077, 0.259) | 0.128 (0.075, 0.33) | ||||||||||||||
| Taxane_CT | count | 233 | 233 | 233 | 233 | |||||||||||||
| time | 14 (10, 28) | 14 (10, 28) | 14 (10, 28) | 14 (10, 28) | ||||||||||||||
| n | 23 (15, 50) | 5 (2, 11) | 5 (2, 11) | 5 (2, 10) | ||||||||||||||
| post_p | 0.3 (0.11, 0.46) | 0.41 (0.23, 0.48) | 0.4 (0.15, 0.47) | 0.4 (0.22, 0.48) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.128 (0.105, 0.174) | 0.158 (0.101, 0.29) | 0.135 (0.075, 0.272) | 0.133 (0.074, 0.311) | ||||||||||||||
| Platinum_CT | count | 22 | 22 | 22 | 22 | |||||||||||||
| time | 12 (8, 17) | 12 (8, 17) | 12 (8, 17) | 12 (8, 17) | ||||||||||||||
| n | 18 (14, 26) | 4 (0, 6) | 4 (1, 7) | 4 (2, 8) | ||||||||||||||
| post_p | 0.25 (0.13, 0.42) | 0.37 (0.16, 0.47) | 0.46 (0.38, 0.5) | 0.4 (0.3, 0.47) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.141 (0.114, 0.172) | 0.208 (0.094, 0.474) | 0.085 (0.003, 0.166) | 0.113 (0.064, 0.21) | ||||||||||||||
| PARPi | count | 18 | 18 | 18 | 18 | |||||||||||||
| time | 12 (9, 19) | 12 (9, 19) | 12 (9, 19) | 12 (9, 19) | ||||||||||||||
| n | 19 (14, 33) | 5 (3, 7) | 4 (1, 7) | 4 (1, 9) | ||||||||||||||
| post_p | 0.31 (0.13, 0.41) | 0.39 (0.25, 0.47) | 0.45 (0.43, 0.5) | 0.43 (0.36, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.147 (0.115, 0.196) | 0.183 (0.108, 0.34) | 0.117 (0.066, 0.202) | 0.123 (0.082, 0.358) | ||||||||||||||
| TP53+ | ARSi | count | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | ||||||||
| time | 18 (8, 32) | 18 (8, 32) | 18 (8, 32) | 18 (8, 32) | 18 (8, 32) | 18 (8, 32) | 18 (8, 32) | 18 (8, 32) | ||||||||||
| n | 16 (8, 32) | 10 (5, 23) | 4 (1, 8) | 3 (1, 7) | 5 (1, 9) | 4 (0, 9) | 3 (1, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.34 (0.15, 0.48) | 0.37 (0.14, 0.47) | 0.37 (0.25, 0.48) | 0.39 (0.21, 0.48) | 0.41 (0.23, 0.49) | 0.41 (0.27, 0.49) | 0.41 (0.25, 0.48) | 0.4 (0.22, 0.49) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.138 (0.097, 0.179) | 0.14 (0.102, 0.235) | 0.133 (0.079, 0.366) | 0.14 (0.077, 0.484) | 0.147 (0.09, 0.291) | 0.16 (0.101, 0.448) | 0.142 (0.078, 0.317) | 0.126 (0.071, 0.397) | ||||||||||
| Taxane_CT | count | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | |||||||||
| time | 20 (10, 33) | 20 (10, 33) | 20 (10, 33) | 20 (10, 33) | 20 (10, 33) | 20 (10, 33) | 20 (10, 33) | 20 (10, 33) | ||||||||||
| n | 20 (9, 34) | 12 (5, 23) | 4 (1, 8) | 3 (1, 9) | 5 (2, 11) | 5 (1, 10) | 4 (1, 8) | 4 (1, 8) | ||||||||||
| post_p | 0.33 (0.08, 0.48) | 0.34 (0.18, 0.48) | 0.38 (0.21, 0.48) | 0.4 (0.19, 0.46) | 0.36 (0.2, 0.48) | 0.4 (0.23, 0.48) | 0.37 (0.24, 0.46) | 0.4 (0.19, 0.48) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.134 (0.103, 0.191) | 0.132 (0.105, 0.215) | 0.148 (0.079, 0.348) | 0.131 (0.069, 0.43) | 0.167 (0.11, 0.313) | 0.157 (0.102, 0.356) | 0.133 (0.068, 0.291) | 0.129 (0.076, 0.225) | ||||||||||
| Platinum_CT | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | 12 (9, 17) | ||||||||||
| n | 11 (10, 14) | 7 (4, 13) | 3 (1, 5) | 3 (1, 5) | 2 (1, 4) | 3 (1, 3) | 2 (1, 2) | 0 (0, 3) | ||||||||||
| post_p | 0.36 (0.19, 0.44) | 0.16 (0.11, 0.43) | 0.46 (0.45, 0.48) | 0.44 (0.38, 0.47) | 0.46 (0.38, 0.49) | 0.39 (0.34, 0.46) | 0.42 (0.4, 0.42) | 0.49 (0.49, 0.49) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.166 (0.14, 0.209) | 0.205 (0.086, 0.274) | 0.116 (0.062, 0.177) | 0.075 (0.069, 0.707) | 0.182 (0.036, 0.21) | 0.297 (0.242, 0.412) | 0.202 (0.105, 4.715) | 0.242 (0.242, 0.242) | ||||||||||
| PARPi | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 12 (7, 16) | 12 (7, 16) | 12 (7, 16) | 12 (7, 16) | 12 (7, 16) | 12 (7, 16) | 12 (7, 16) | 12 (7, 16) | ||||||||||
| n | 12 (9, 16) | 8 (6, 10) | 0 (0, 1) | 4 (3, 5) | 4 (3, 5) | 2 (1, 2) | 2 (0, 3) | 2 (1, 3) | ||||||||||
| post_p | 0.3 (0.25, 0.34) | 0.35 (0.27, 0.43) | 0.48 (0.48, 0.48) | 0.49 (0.49, 0.5) | 0.43 (0.42, 0.43) | 0.46 (0.43, 0.48) | 0.46 (0.46, 0.46) | 0.42 (0.38, 0.45) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.142 (0.137, 0.147) | 0.132 (0.117, 0.147) | 0 (0, 0) | 0.084 (0.06, 0.108) | 0.202 (0.13, 0.273) | 0.392 (0.161, 0.622) | 0.076 (0.076, 0.076) | 0.165 (0.099, 0.231) | ||||||||||
| HRD+ | ARSi | count | 214 | 214 | 214 | 214 | 214 | 214 | 214 | 214 | ||||||||
| time | 21 (14, 32) | 21 (14, 32) | 21 (14, 32) | 21 (14, 32) | 21 (14, 32) | 21 (14, 32) | 21 (14, 32) | 21 (14, 32) | ||||||||||
| n | 6 (2, 12) | 6 (3, 12) | 4 (1, 8) | 4 (1, 8) | 5 (2, 9) | 4 (2, 8) | 4 (2, 8) | 4 (2, 8) | ||||||||||
| post_p | 0.33 (0.13, 0.47) | 0.34 (0.14, 0.47) | 0.37 (0.18, 0.48) | 0.39 (0.21, 0.48) | 0.36 (0.17, 0.48) | 0.38 (0.18, 0.46) | 0.38 (0.18, 0.48) | 0.4 (0.21, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.122 (0.081, 0.241) | 0.127 (0.078, 0.258) | 0.144 (0.075, 0.357) | 0.139 (0.071, 0.314) | 0.136 (0.073, 0.382) | 0.153 (0.073, 0.312) | 0.13 (0.073, 0.324) | 0.136 (0.076, 0.305) | ||||||||||
| Taxane_CT | count | 197 | 197 | 197 | 197 | 197 | 197 | 197 | 197 | |||||||||
| time | 22 (16, 32) | 22 (16, 32) | 22 (16, 32) | 22 (16, 32) | 22 (16, 32) | 22 (16, 32) | 22 (16, 32) | 22 (16, 32) | ||||||||||
| n | 6 (3, 13) | 6 (3, 12) | 5 (2, 9) | 5 (2, 9) | 5 (2, 9) | 4 (2, 9) | 5 (2, 9) | 4 (2, 8) | ||||||||||
| post_p | 0.33 (0.1, 0.46) | 0.32 (0.13, 0.47) | 0.36 (0.18, 0.48) | 0.38 (0.2, 0.48) | 0.38 (0.19, 0.47) | 0.38 (0.17, 0.48) | 0.37 (0.18, 0.46) | 0.37 (0.16, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.123 (0.079, 0.229) | 0.124 (0.078, 0.272) | 0.137 (0.078, 0.269) | 0.135 (0.076, 0.288) | 0.125 (0.074, 0.343) | 0.133 (0.077, 0.313) | 0.133 (0.084, 0.294) | 0.125 (0.078, 0.328) | ||||||||||
| TEfus+ | ARSi | count | 65 | 65 | 65 | 65 | 65 | 65 | 65 | 65 | ||||||||
| time | 21 (12, 34) | 21 (12, 34) | 21 (12, 34) | 21 (12, 34) | 21 (12, 34) | 21 (12, 34) | 21 (12, 34) | 21 (12, 34) | ||||||||||
| n | 5 (2, 12) | 13 (7, 23) | 5 (2, 12) | 3 (1, 8) | 6 (3, 10) | 5 (1, 11) | 4 (1, 7) | 4 (1, 8) | ||||||||||
| post_p | 0.36 (0.18, 0.48) | 0.34 (0.15, 0.47) | 0.33 (0.12, 0.44) | 0.38 (0.19, 0.46) | 0.41 (0.15, 0.49) | 0.39 (0.22, 0.48) | 0.34 (0.12, 0.48) | 0.42 (0.23, 0.49) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.163 (0.103, 0.309) | 0.137 (0.103, 0.205) | 0.134 (0.079, 0.292) | 0.13 (0.081, 0.286) | 0.145 (0.1, 0.32) | 0.153 (0.095, 0.257) | 0.172 (0.073, 0.481) | 0.119 (0.074, 0.255) | ||||||||||
| Taxane_CT | count | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | |||||||||
| time | 22 (13, 31) | 22 (13, 31) | 22 (13, 31) | 22 (13, 31) | 22 (13, 31) | 22 (13, 31) | 22 (13, 31) | 22 (13, 31) | ||||||||||
| n | 5 (2, 12) | 13 (8, 22) | 6 (2, 10) | 4 (1, 8) | 5 (2, 9) | 5 (2, 8) | 4 (1, 7) | 4 (2, 8) | ||||||||||
| post_p | 0.37 (0.19, 0.5) | 0.35 (0.1, 0.47) | 0.31 (0.16, 0.47) | 0.38 (0.14, 0.47) | 0.42 (0.2, 0.48) | 0.41 (0.16, 0.49) | 0.38 (0.2, 0.48) | 0.38 (0.17, 0.48) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.152 (0.098, 0.296) | 0.138 (0.102, 0.194) | 0.135 (0.078, 0.342) | 0.138 (0.068, 0.465) | 0.15 (0.097, 0.329) | 0.157 (0.095, 0.361) | 0.117 (0.063, 0.246) | 0.119 (0.074, 0.287) | ||||||||||
| PARPi | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | ||||||||||
| n | 1 (1, 1) | 6 (6, 6) | 0 (0, 0) | 3 (3, 3) | 6 (6, 6) | 5 (5, 5) | 1 (1, 1) | 3 (3, 3) | ||||||||||
| post_p | 0.46 (0.46, 0.46) | 0.48 (0.48, 0.48) | NA (NA, NA) | 0.4 (0.4, 0.4) | 0.17 (0.17, 0.17) | 0.13 (0.13, 0.13) | 0.37 (0.37, 0.37) | 0.48 (0.48, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.151 (0.151, 0.151) | 0.118 (0.118, 0.118) | NA (NA, NA) | 0.151 (0.151, 0.151) | 0.223 (0.223, 0.223) | 0.361 (0.361, 0.361) | 13.589 (13.589, 13.589) | 0.041 (0.041, 0.041) |