Setting description

Equal randomization: Platinum_CT and PARPi more effective in the HRD+ biomarker signature (cfr scen 6)

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other ARSi Taxane_CT Platinum_CT PARPi
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.091, shape = 1.05 scale = 0.091, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.8, median = 7.7 mean = 10.8, median = 7.7
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.23, hr = 0.81 af = 1.23, hr = 0.81
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.093, shape = 1.05 scale = 0.093, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.5, median = 7.6 mean = 10.5, median = 7.6
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.2, hr = 0.83 af = 1.2, hr = 0.83
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.092, shape = 1.05 scale = 0.092, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 10.7, median = 7.7 mean = 10.7, median = 7.7
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.21, hr = 0.82 af = 1.21, hr = 0.82
HRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.084, shape = 1.05 scale = 0.084, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 11.7, median = 8.4 mean = 11.7, median = 8.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.33, hr = 0.74 af = 1.33, hr = 0.74



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other ARSi Taxane_CT Platinum_CT PARPi
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31

Errors and power


graduation (counts and proportions):
ARSi Taxane_CT Platinum_CT PARPi
all 0 2 13 19
TP53- & AR- 12 12 140 119
TP53+ 1 1 25 17
HRD+ 0 0 291 301
TEfus+ 0 0 18 19
ARSi Taxane_CT Platinum_CT PARPi
all 0.000 0.004 0.026 0.038
TP53- & AR- 0.024 0.024 0.280 0.238
TP53+ 0.002 0.002 0.050 0.034
HRD+ 0.000 0.000 0.582 0.602
TEfus+ 0.000 0.000 0.036 0.038
futility (counts and proportions):
ARSi Taxane_CT Platinum_CT PARPi
all 6 7 0 0
TP53- & AR- 247 233 22 18
TP53+ 74 74 3 2
HRD+ 214 197 0 0
TEfus+ 65 67 0 1
ARSi Taxane_CT Platinum_CT PARPi
all 0.012 0.014 0.000 0.000
TP53- & AR- 0.494 0.466 0.044 0.036
TP53+ 0.148 0.148 0.006 0.004
HRD+ 0.428 0.394 0.000 0.000
TEfus+ 0.130 0.134 0.000 0.002
max sample size (counts and proportions):
ARSi Taxane_CT Platinum_CT PARPi
all 0 0 0 0
TP53- & AR- 16 12 18 14
TP53+ 1 6 8 12
HRD+ 0 0 0 0
TEfus+ 0 0 0 0
ARSi Taxane_CT Platinum_CT PARPi
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.032 0.024 0.036 0.028
TP53+ 0.002 0.012 0.016 0.024
HRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.000


Errors & power

The overall error was 0.268.
The corresponding errors separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.026       0.030       0.134       0.106 

The overall power was 0.832.
The corresponding power separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.000       0.000       0.582       0.602 

Median results at the end of the trial

By signature:
signature var Control ARSi Taxane_CT Platinum_CT PARPi
all graduation 0 0 2 13 19
futility 0 6 7 0 0
max_n 0 0 0 0 0
n 280 (245, 324) 208 (148, 275) 213 (144, 282) 232 (159, 287) 231 (171, 286)
n_unique 257 (224, 296) 194 (136, 257) 198 (134, 262) 214 (145, 265) 213 (155, 262)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 22 (15, 30) 27 (5, 34) 10 (4, 33) 27 (12, 34)
post_p NA (NA, NA) 0.4 (0.07, 0.86) 0.43 (0.07, 0.84) 1 (0.95, 1) 1 (0.93, 1)
rate 0.111 (0.102, 0.122) 0.113 (0.102, 0.126) 0.113 (0.103, 0.126) 0.082 (0.073, 0.091) 0.081 (0.072, 0.092)
TP53- & AR- graduation 0 12 12 140 119
futility 0 247 233 22 18
max_n 0 16 12 18 14
n 120 (95, 149) 82 (27, 122) 83 (27, 123) 96 (29, 130) 96 (32, 129)
n_unique 111 (87, 139) 75 (25, 114) 78 (26, 116) 89 (27, 122) 89 (29, 120)
time_trial 36 (36, 36) 32 (11, 36) 36 (11, 36) 36 (12, 36) 36 (13, 36)
time_stop NA (NA, NA) 15 (9, 30) 14 (10, 28) 15 (10, 32) 15 (10, 29)
post_p NA (NA, NA) 0.38 (0.08, 0.83) 0.39 (0.07, 0.85) 0.95 (0.67, 1) 0.94 (0.61, 1)
rate 0.111 (0.098, 0.129) 0.115 (0.098, 0.143) 0.114 (0.097, 0.144) 0.084 (0.068, 0.101) 0.084 (0.069, 0.102)
TP53+ graduation 0 1 1 25 17
futility 0 74 74 3 2
max_n 0 1 6 8 12
n 119 (102, 142) 105 (64, 125) 104 (68, 129) 104 (80, 127) 105 (80, 129)
n_unique 109 (92, 130) 97 (59, 115) 96 (63, 119) 95 (73, 117) 97 (74, 118)
time_trial 36 (36, 36) 36 (24, 36) 36 (27, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 18 (8, 32) 19 (9, 33) 12 (8, 23) 18 (10, 32)
post_p NA (NA, NA) 0.41 (0.07, 0.83) 0.42 (0.07, 0.8) 0.96 (0.66, 1) 0.96 (0.75, 1)
rate 0.111 (0.098, 0.129) 0.113 (0.098, 0.133) 0.114 (0.1, 0.133) 0.084 (0.07, 0.099) 0.082 (0.07, 0.097)
HRD+ graduation 0 0 0 291 301
futility 0 214 197 0 0
max_n 0 0 0 0 0
n 84 (67, 105) 56 (28, 88) 59 (30, 91) 59 (26, 88) 56 (27, 87)
n_unique 78 (61, 98) 51 (25, 80) 54 (28, 85) 53 (24, 81) 52 (25, 79)
time_trial 36 (36, 36) 36 (17, 36) 36 (19, 36) 33 (15, 36) 32 (16, 36)
time_stop NA (NA, NA) 21 (14, 32) 22 (16, 32) 24 (14, 34) 23 (14, 33)
post_p NA (NA, NA) 0.28 (0.05, 0.72) 0.26 (0.05, 0.72) 1 (1, 1) 1 (1, 1)
rate 0.112 (0.095, 0.131) 0.113 (0.094, 0.145) 0.114 (0.095, 0.139) 0.036 (0.028, 0.046) 0.036 (0.028, 0.045)
TEfus+ graduation 0 0 0 18 19
futility 0 65 67 0 1
max_n 0 0 0 0 0
n 104 (86, 125) 79 (49, 104) 80 (48, 109) 86 (58, 108) 83 (60, 108)
n_unique 95 (79, 113) 72 (44, 97) 74 (43, 100) 78 (52, 99) 76 (54, 98)
time_trial 36 (36, 36) 36 (29, 36) 36 (28, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 21 (12, 34) 22 (13, 31) 12 (10, 20) 18 (11, 30)
post_p NA (NA, NA) 0.43 (0.06, 0.82) 0.38 (0.07, 0.82) 0.98 (0.8, 1) 0.99 (0.86, 1)
rate 0.112 (0.096, 0.127) 0.113 (0.096, 0.135) 0.113 (0.097, 0.132) 0.074 (0.062, 0.091) 0.073 (0.06, 0.087)


By subgroup combinations:
subtype var Control ARSi Taxane_CT Platinum_CT PARPi
—- graduation 0 259 248 170 144
futility 0 0 0 0 0
max_n 0 16 12 18 14
n 73 (56, 94) 52 (17, 76) 52 (17, 77) 61 (20, 84) 63 (20, 83)
n_unique 67 (51, 88) 48 (16, 72) 50 (16, 73) 57 (18, 80) 58 (19, 79)
post_p NA (NA, NA) 0.46 (0.09, 0.84) 0.46 (0.1, 0.86) 0.52 (0.14, 0.89) 0.51 (0.11, 0.89)
rate 0.112 (0.094, 0.133) 0.116 (0.095, 0.147) 0.113 (0.094, 0.149) 0.112 (0.089, 0.135) 0.112 (0.092, 0.135)
—+ graduation 0 280 261 181 151
futility 0 0 0 0 0
max_n 0 16 12 18 14
n 15 (9, 22) 9 (3, 17) 9 (3, 18) 12 (3, 19) 12 (4, 20)
n_unique 14 (8, 20) 8 (2, 16) 8 (3, 17) 11 (3, 17) 11 (3, 18)
post_p NA (NA, NA) 0.44 (0.2, 0.83) 0.47 (0.19, 0.81) 0.49 (0.16, 0.81) 0.5 (0.17, 0.81)
rate 0.112 (0.077, 0.161) 0.119 (0.074, 0.214) 0.12 (0.075, 0.211) 0.117 (0.072, 0.185) 0.114 (0.074, 0.178)
–+- graduation 0 75 77 39 37
futility 0 0 0 0 0
max_n 0 1 6 8 12
n 37 (29, 47) 34 (21, 43) 35 (23, 44) 36 (24, 44) 36 (27, 45)
n_unique 34 (26, 44) 32 (20, 40) 32 (22, 41) 33 (22, 41) 33 (25, 42)
post_p NA (NA, NA) 0.48 (0.14, 0.88) 0.48 (0.14, 0.82) 0.48 (0.13, 0.85) 0.51 (0.14, 0.89)
rate 0.112 (0.09, 0.141) 0.113 (0.088, 0.148) 0.115 (0.092, 0.147) 0.114 (0.09, 0.144) 0.113 (0.088, 0.145)
–++ graduation 0 112 122 51 49
futility 0 0 0 0 0
max_n 0 1 6 8 12
n 25 (19, 34) 23 (11, 31) 23 (11, 30) 24 (14, 33) 24 (16, 32)
n_unique 23 (17, 31) 21 (10, 29) 21 (10, 29) 22 (13, 30) 22 (14, 29)
post_p NA (NA, NA) 0.48 (0.17, 0.87) 0.48 (0.16, 0.83) 0.5 (0.14, 0.83) 0.52 (0.18, 0.86)
rate 0.113 (0.085, 0.149) 0.114 (0.084, 0.159) 0.116 (0.085, 0.158) 0.113 (0.083, 0.153) 0.111 (0.084, 0.146)
-+– graduation 0 345 336 357 359
futility 0 0 0 0 0
max_n 0 16 12 16 12
n 16 (10, 23) 8 (3, 19) 8 (3, 18) 9 (3, 19) 10 (3, 18)
n_unique 14 (9, 22) 7 (2, 18) 8 (2, 17) 9 (3, 17) 9 (3, 16)
post_p NA (NA, NA) 0.3 (0.09, 0.59) 0.31 (0.1, 0.61) 0.92 (0.69, 0.99) 0.92 (0.63, 1)
rate 0.11 (0.08, 0.163) 0.12 (0.078, 0.216) 0.119 (0.077, 0.204) 0.036 (0.016, 0.065) 0.037 (0.018, 0.066)
-+-+ graduation 0 352 340 362 362
futility 0 0 0 0 0
max_n 0 16 12 16 12
n 16 (10, 23) 8 (3, 18) 8 (3, 18) 10 (3, 19) 9 (3, 18)
n_unique 15 (8, 21) 7 (2, 16) 7 (2, 17) 9 (2, 18) 8 (3, 17)
post_p NA (NA, NA) 0.32 (0.12, 0.61) 0.31 (0.1, 0.62) 0.92 (0.67, 0.99) 0.92 (0.66, 0.99)
rate 0.113 (0.074, 0.168) 0.117 (0.075, 0.215) 0.119 (0.077, 0.226) 0.037 (0.019, 0.066) 0.037 (0.017, 0.065)
-++- graduation 0 240 233 307 311
futility 0 0 0 0 0
max_n 0 1 6 7 12
n 9 (5, 13) 6 (2, 12) 6 (2, 12) 6 (2, 11) 5 (2, 11)
n_unique 8 (4, 13) 6 (2, 11) 6 (2, 11) 5 (2, 11) 5 (1, 10)
post_p NA (NA, NA) 0.35 (0.11, 0.59) 0.34 (0.13, 0.63) 0.83 (0.57, 0.97) 0.82 (0.55, 0.96)
rate 0.116 (0.07, 0.197) 0.122 (0.069, 0.253) 0.118 (0.066, 0.221) 0.037 (0.013, 0.077) 0.037 (0.012, 0.08)
-+++ graduation 0 254 253 313 315
futility 0 0 0 0 0
max_n 0 1 6 7 12
n 9 (5, 14) 6 (2, 11) 7 (2, 12) 6 (2, 11) 6 (2, 11)
n_unique 8 (4, 13) 5 (2, 11) 6 (2, 11) 5 (1, 10) 5 (2, 10)
post_p NA (NA, NA) 0.34 (0.14, 0.63) 0.34 (0.15, 0.6) 0.8 (0.54, 0.95) 0.81 (0.55, 0.97)
rate 0.114 (0.063, 0.191) 0.121 (0.066, 0.256) 0.117 (0.068, 0.229) 0.039 (0.015, 0.078) 0.036 (0.012, 0.076)
+— graduation 0 6 9 13 19
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (8, 17) 12 (8, 17) 12 (8, 16) 12 (7, 17) 12 (8, 17)
n_unique 10 (6, 15) 11 (7, 16) 11 (7, 15) 11 (7, 15) 11 (7, 15)
post_p NA (NA, NA) 0.5 (0.17, 0.84) 0.48 (0.17, 0.84) 0.5 (0.18, 0.82) 0.52 (0.19, 0.81)
rate 0.114 (0.074, 0.18) 0.114 (0.072, 0.176) 0.118 (0.076, 0.18) 0.113 (0.075, 0.173) 0.112 (0.077, 0.172)
+–+ graduation 0 66 69 27 32
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 10 (6, 14) 9 (5, 14) 9 (5, 14) 9 (5, 13) 9 (5, 14)
n_unique 9 (5, 13) 8 (5, 13) 8 (4, 13) 9 (5, 13) 8 (4, 13)
post_p NA (NA, NA) 0.48 (0.2, 0.81) 0.48 (0.19, 0.84) 0.48 (0.19, 0.8) 0.5 (0.19, 0.81)
rate 0.116 (0.069, 0.189) 0.117 (0.072, 0.195) 0.119 (0.068, 0.205) 0.119 (0.074, 0.186) 0.112 (0.071, 0.195)
+-+- graduation 0 75 77 39 37
futility 0 0 0 0 0
max_n 0 1 6 8 12
n 10 (6, 15) 9 (4, 14) 9 (5, 13) 10 (5, 14) 10 (5, 14)
n_unique 9 (5, 13) 8 (4, 12) 8 (4, 12) 9 (4, 13) 9 (5, 13)
post_p NA (NA, NA) 0.47 (0.17, 0.79) 0.5 (0.18, 0.78) 0.49 (0.2, 0.82) 0.5 (0.21, 0.83)
rate 0.112 (0.07, 0.184) 0.12 (0.072, 0.198) 0.114 (0.075, 0.195) 0.115 (0.069, 0.18) 0.114 (0.072, 0.182)
+-++ graduation 0 112 122 51 49
futility 0 0 0 0 0
max_n 0 1 6 8 12
n 10 (6, 15) 9 (4, 14) 9 (4, 14) 9 (5, 14) 9 (5, 15)
n_unique 9 (6, 14) 8 (3, 13) 8 (3, 13) 8 (4, 13) 9 (4, 13)
post_p NA (NA, NA) 0.47 (0.16, 0.8) 0.5 (0.19, 0.81) 0.49 (0.19, 0.8) 0.53 (0.21, 0.82)
rate 0.114 (0.069, 0.185) 0.12 (0.073, 0.212) 0.113 (0.072, 0.218) 0.117 (0.069, 0.194) 0.108 (0.07, 0.18)
++– graduation 0 215 199 299 308
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (5, 13) 7 (2, 11) 7 (3, 12) 6 (2, 11) 6 (2, 11)
n_unique 8 (5, 12) 6 (2, 10) 6 (2, 11) 5 (2, 10) 5 (2, 10)
post_p NA (NA, NA) 0.33 (0.13, 0.59) 0.34 (0.14, 0.59) 0.82 (0.55, 0.97) 0.82 (0.58, 0.97)
rate 0.115 (0.068, 0.191) 0.12 (0.069, 0.217) 0.119 (0.063, 0.252) 0.037 (0.013, 0.08) 0.035 (0.013, 0.077)
++-+ graduation 0 232 226 305 313
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 9 (5, 13) 6 (2, 11) 7 (2, 12) 6 (2, 11) 5 (2, 10)
n_unique 8 (4, 12) 5 (2, 10) 6 (2, 11) 5 (2, 10) 5 (2, 10)
post_p NA (NA, NA) 0.33 (0.12, 0.61) 0.34 (0.11, 0.6) 0.8 (0.55, 0.97) 0.81 (0.57, 0.96)
rate 0.112 (0.068, 0.192) 0.124 (0.07, 0.265) 0.115 (0.068, 0.24) 0.037 (0.01, 0.073) 0.035 (0.012, 0.072)
+++- graduation 0 240 233 307 311
futility 0 0 0 0 0
max_n 0 1 6 7 12
n 9 (5, 13) 6 (2, 11) 7 (2, 12) 6 (2, 11) 6 (2, 11)
n_unique 8 (4, 13) 6 (2, 10) 6 (2, 11) 5 (2, 10) 5 (2, 10)
post_p NA (NA, NA) 0.35 (0.15, 0.63) 0.35 (0.12, 0.6) 0.82 (0.57, 0.96) 0.83 (0.53, 0.96)
rate 0.119 (0.069, 0.197) 0.112 (0.065, 0.244) 0.116 (0.068, 0.225) 0.036 (0.014, 0.076) 0.037 (0.014, 0.079)
++++ graduation 0 254 253 313 315
futility 0 0 0 0 0
max_n 0 1 6 7 12
n 9 (5, 14) 6 (2, 12) 6 (2, 12) 6 (2, 11) 6 (2, 11)
n_unique 8 (4, 13) 5 (2, 11) 6 (2, 11) 5 (1, 10) 5 (2, 10)
post_p NA (NA, NA) 0.35 (0.14, 0.6) 0.32 (0.13, 0.59) 0.81 (0.54, 0.96) 0.82 (0.55, 0.97)
rate 0.114 (0.066, 0.19) 0.121 (0.066, 0.235) 0.123 (0.075, 0.244) 0.038 (0.014, 0.075) 0.036 (0.013, 0.074)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var ARSi Taxane_CT Platinum_CT PARPi
all count 2 13 19
time_stop 5 (5, 5) 10 (4, 33) 27 (12, 34)
n_trt 32 (28, 36) 67 (25, 150) 155 (87, 225)
n_control 34 (24, 44) 70 (31, 265) 203 (82, 275)
post_p 0.9 (0.88, 0.92) 1 (0.92, 1) 1 (0.97, 1)
order 1 (1, 1) 1 (1, 5) 3 (1, 5)
TP53- & AR- count 12 12 140 119
time_stop 10 (8, 14) 14 (10, 16) 16 (10, 33) 17 (10, 30)
n_trt 26 (25, 31) 32 (25, 42) 44 (26, 95) 41 (26, 94)
n_control 24 (22, 38) 38 (30, 48) 47 (25, 104) 48 (26, 97)
post_p 0.9 (0.86, 0.97) 0.94 (0.89, 0.98) 0.97 (0.89, 1) 0.96 (0.89, 1)
order 1 (1, 1.9) 1 (1, 2) 1 (1, 3) 1 (1, 3)
TP53+ count 1 1 25 17
time_stop 9 (9, 9) 8 (8, 8) 11 (8, 24) 21 (10, 32)
n_trt 32 (32, 32) 25 (25, 25) 34 (25, 60) 64 (27, 103)
n_control 23 (23, 23) 15 (15, 15) 32 (22, 72) 71 (33, 113)
post_p 0.92 (0.92, 0.92) 0.99 (0.99, 0.99) 0.98 (0.9, 1) 1 (0.95, 1)
order 1 (1, 1) 1 (1, 1) 1 (1, 3) 2 (1, 3.4)
HRD+ count 291 301
time_stop 24 (14, 34) 23 (14, 33)
n_trt 42 (26, 76) 43 (26, 74)
n_control 51 (25, 82) 47 (25, 79)
post_p 1 (0.98, 1) 1 (0.99, 1)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 18 19
time_stop 12 (10, 20) 20 (11, 30)
n_trt 30 (26, 51) 43 (25, 72)
n_control 30 (24, 52) 49 (25, 85)
post_p 0.99 (0.91, 1) 0.99 (0.97, 1)
order 1.5 (1, 4) 2 (1, 4)
Futility:
signature var ARSi Taxane_CT Platinum_CT PARPi
all count 6 7
time_stop 22 (15, 30) 31 (23, 34)
n_trt 110 (77, 188) 132 (98, 188)
n_control 157 (110, 220) 227 (180, 265)
post_p 0.01 (0.01, 0.2) 0.01 (0, 0.1)
order 3.5 (2.5, 5) 5 (3.6, 6)
TP53- & AR- count 247 233 22 18
time_stop 16 (9, 30) 14 (10, 28) 12 (8, 17) 12 (9, 19)
n_trt 40 (26, 86) 37 (26, 80) 30 (25, 40) 29 (26, 53)
n_control 44 (23, 87) 38 (23, 86) 32 (17, 43) 34 (20, 54)
post_p 0.18 (0.05, 0.28) 0.16 (0.04, 0.27) 0.13 (0.05, 0.23) 0.17 (0.05, 0.26)
order 1 (1, 3) 1 (1, 3) 1 (1, 2) 1 (1, 2)
TP53+ count 74 74 3 2
time_stop 18 (8, 32) 20 (10, 33) 12 (9, 17) 12 (7, 16)
n_trt 54 (26, 87) 58 (27, 101) 28 (27, 42) 34 (27, 41)
n_control 54 (24, 102) 56 (29, 107) 43 (26, 61) 36 (21, 52)
post_p 0.08 (0.02, 0.24) 0.08 (0.01, 0.23) 0.06 (0.02, 0.13) 0.13 (0.13, 0.14)
order 2 (1, 4.7) 2 (1, 4) 1 (1, 1.8) 1 (1, 1)
HRD+ count 214 197
time_stop 21 (14, 32) 22 (16, 32)
n_trt 36 (26, 60) 39 (27, 68)
n_control 43 (24, 70) 47 (28, 77)
post_p 0.1 (0.01, 0.24) 0.09 (0.01, 0.21)
order 2 (1, 4) 2 (1, 4)
TEfus+ count 65 67 1
time_stop 21 (12, 34) 22 (13, 31) 15 (15, 15)
n_trt 44 (27, 77) 49 (29, 76) 25 (25, 25)
n_control 53 (25, 99) 60 (31, 97) 37 (37, 37)
post_p 0.08 (0.01, 0.19) 0.07 (0.01, 0.21) 0.02 (0.02, 0.02)
order 3 (1, 4.6) 3 (1, 5) 1 (1, 1)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Taxane_CT count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 12 (10, 13) 0 (0, 1) 5 (3, 7) 2 (1, 4) 1 (0, 2) 1 (0, 2) 0 (0, 0) 1 (0, 2) 2 (0, 3) 2 (1, 3) 2 (2, 2) 0 (0, 1) 2 (2, 2) 0 (0, 1) 1 (0, 2) 0 (0, 0)
post_p 0.6 (0.58, 0.62) NA (NA, NA) 0.57 (0.56, 0.57) 0.57 (0.56, 0.59) 0.6 (0.6, 0.6) 0.53 (0.53, 0.53) NA (NA, NA) 0.5 (0.5, 0.5) 0.62 (0.62, 0.62) 0.53 (0.52, 0.53) 0.51 (0.51, 0.51) 0.53 (0.53, 0.53) 0.57 (0.57, 0.57) 0.54 (0.54, 0.54) 0.58 (0.58, 0.58) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.044 (0.009, 0.078) 0 (0, 0) 0.045 (0.009, 0.08) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.177 (0.177, 0.177) 0 (0, 0) 0.066 (0.013, 0.119) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA)
Platinum_CT count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
time 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33)
n 14 (6, 39) 4 (0, 10) 13 (4, 29) 8 (1, 18) 3 (2, 8) 3 (1, 8) 2 (1, 7) 2 (1, 3) 4 (1, 13) 3 (1, 7) 3 (0, 7) 3 (1, 9) 2 (0, 5) 2 (1, 4) 2 (0, 8) 3 (0, 5)
post_p 0.7 (0.52, 0.93) 0.59 (0.53, 0.8) 0.59 (0.53, 0.76) 0.64 (0.51, 0.79) 0.59 (0.52, 0.87) 0.69 (0.52, 0.9) 0.59 (0.53, 0.74) 0.55 (0.51, 0.82) 0.62 (0.52, 0.75) 0.65 (0.51, 0.76) 0.56 (0.52, 0.83) 0.56 (0.52, 0.75) 0.53 (0.51, 0.68) 0.64 (0.52, 0.74) 0.62 (0.52, 0.81) 0.63 (0.54, 0.91)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.087 (0.035, 0.127) 0.077 (0, 0.106) 0.095 (0, 0.123) 0.08 (0, 0.123) 0.007 (0, 0.069) 0.02 (0, 0.045) 0 (0, 0.059) 0 (0, 0.074) 0.062 (0, 0.126) 0.031 (0, 0.114) 0.052 (0, 0.13) 0.07 (0, 0.129) 0.038 (0, 0.073) 0 (0, 0.057) 0 (0, 0.058) 0.014 (0, 0.06)
PARPi count 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19
time 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34)
n 36 (16, 59) 5 (2, 10) 26 (12, 32) 14 (7, 23) 6 (2, 14) 6 (2, 12) 3 (0, 8) 3 (1, 6) 9 (3, 12) 5 (0, 8) 9 (2, 14) 6 (0, 9) 3 (1, 8) 3 (1, 6) 5 (1, 9) 4 (2, 8)
post_p 0.65 (0.54, 0.87) 0.72 (0.54, 0.8) 0.62 (0.55, 0.86) 0.69 (0.55, 0.88) 0.88 (0.55, 0.97) 0.86 (0.62, 0.99) 0.76 (0.55, 0.88) 0.65 (0.56, 0.9) 0.6 (0.51, 0.85) 0.62 (0.53, 0.82) 0.58 (0.51, 0.67) 0.64 (0.54, 0.8) 0.74 (0.56, 0.91) 0.65 (0.58, 0.83) 0.72 (0.57, 0.93) 0.75 (0.58, 0.92)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.103 (0.072, 0.122) 0.079 (0.048, 0.171) 0.093 (0.072, 0.118) 0.095 (0.078, 0.11) 0.042 (0, 0.059) 0.026 (0, 0.046) 0.04 (0, 0.052) 0.042 (0, 0.066) 0.093 (0.048, 0.13) 0.094 (0.072, 0.122) 0.106 (0.063, 0.132) 0.086 (0.055, 0.119) 0.033 (0, 0.061) 0.025 (0, 0.05) 0.037 (0, 0.065) 0.018 (0, 0.048)
TP53- & AR- ARSi count 12 12 12 12
time 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14)
n 19 (15, 22) 3 (2, 5) 2 (1, 4) 4 (1, 5)
post_p 0.82 (0.75, 0.93) 0.59 (0.53, 0.72) 0.54 (0.52, 0.63) 0.58 (0.52, 0.69)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.079 (0.055, 0.097) 0 (0, 0.174) 0 (0, 0.043) 0.056 (0, 0.113)
Taxane_CT count 12 12 12 12
time 14 (10, 16) 14 (10, 16) 14 (10, 16) 14 (10, 16)
n 20 (18, 26) 4 (1, 6) 4 (2, 9) 4 (1, 6)
post_p 0.85 (0.76, 0.97) 0.58 (0.52, 0.75) 0.56 (0.5, 0.82) 0.56 (0.54, 0.75)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.071 (0.044, 0.101) 0.081 (0, 0.112) 0.05 (0, 0.134) 0.059 (0, 0.089)
Platinum_CT count 140 140 140 140
time 16 (10, 33) 16 (10, 33) 16 (10, 33) 16 (10, 33)
n 28 (17, 59) 5 (2, 13) 5 (2, 15) 5 (2, 12)
post_p 0.78 (0.71, 0.93) 0.68 (0.52, 0.81) 0.73 (0.55, 0.96) 0.73 (0.55, 0.96)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.086 (0.052, 0.107) 0.071 (0, 0.127) 0.025 (0, 0.056) 0.02 (0, 0.054)
PARPi count 119 119 119 119
time 17 (10, 30) 17 (10, 30) 17 (10, 30) 17 (10, 30)
n 27 (16, 57) 5 (2, 12) 5 (2, 14) 5 (2, 13)
post_p 0.75 (0.71, 0.88) 0.66 (0.54, 0.84) 0.75 (0.54, 0.95) 0.72 (0.53, 0.94)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.092 (0.061, 0.112) 0.076 (0, 0.143) 0.027 (0, 0.063) 0.027 (0, 0.066)
TP53+ ARSi count 1 1 1 1 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 5 (5, 5) 8 (8, 8) 3 (3, 3) 5 (5, 5) 1 (1, 1) 4 (4, 4) 3 (3, 3) 3 (3, 3)
post_p 0.5 (0.5, 0.5) 0.88 (0.88, 0.88) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.51 (0.51, 0.51) 0.64 (0.64, 0.64) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.098 (0.098, 0.098) 0.068 (0.068, 0.068) 0.107 (0.107, 0.107) 0.044 (0.044, 0.044) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.182 (0.182, 0.182)
Taxane_CT count 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 11 (11, 11) 4 (4, 4) 4 (4, 4) 1 (1, 1) 0 (0, 0) 2 (2, 2) 0 (0, 0) 3 (3, 3)
post_p 0.89 (0.89, 0.89) 0.65 (0.65, 0.65) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) 0.56 (0.56, 0.56)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0)
Platinum_CT count 25 25 25 25 25 25 25 25
time 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24)
n 13 (8, 27) 8 (4, 16) 3 (1, 4) 2 (0, 5) 3 (0, 5) 2 (1, 5) 2 (0, 4) 2 (0, 4)
post_p 0.76 (0.71, 0.87) 0.73 (0.55, 0.84) 0.61 (0.53, 0.75) 0.63 (0.53, 0.73) 0.62 (0.52, 0.83) 0.58 (0.51, 0.71) 0.56 (0.52, 0.65) 0.54 (0.51, 0.85)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.066 (0.023, 0.106) 0.073 (0.035, 0.099) 0 (0, 0.062) 0 (0, 0.071) 0.018 (0, 0.096) 0.067 (0, 0.112) 0 (0, 0.071) 0 (0, 0.078)
PARPi count 17 17 17 17 17 17 17 17
time 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32)
n 23 (10, 32) 13 (3, 25) 4 (1, 11) 4 (2, 8) 4 (1, 10) 4 (1, 8) 3 (1, 9) 3 (1, 10)
post_p 0.8 (0.72, 0.87) 0.73 (0.62, 0.89) 0.73 (0.55, 0.81) 0.7 (0.51, 0.85) 0.6 (0.54, 0.84) 0.66 (0.53, 0.78) 0.6 (0.51, 0.92) 0.71 (0.59, 0.97)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.088 (0.047, 0.104) 0.096 (0.047, 0.113) 0.029 (0, 0.05) 0.02 (0, 0.077) 0.07 (0, 0.108) 0.064 (0, 0.113) 0.023 (0, 0.061) 0.014 (0, 0.054)
HRD+ Platinum_CT count 291 291 291 291 291 291 291 291
time 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34)
n 7 (3, 16) 8 (3, 17) 4 (2, 10) 4 (1, 10) 5 (2, 10) 4 (2, 9) 4 (2, 9) 4 (2, 10)
post_p 0.8 (0.58, 0.98) 0.8 (0.59, 0.97) 0.72 (0.55, 0.91) 0.7 (0.53, 0.9) 0.72 (0.53, 0.91) 0.7 (0.53, 0.9) 0.72 (0.53, 0.91) 0.71 (0.53, 0.92)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.031 (0, 0.063) 0.034 (0, 0.062) 0.03 (0, 0.071) 0.03 (0, 0.064) 0.03 (0, 0.074) 0.03 (0, 0.071) 0.028 (0, 0.069) 0.029 (0, 0.073)
PARPi count 301 301 301 301 301 301 301 301
time 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33)
n 8 (3, 15) 8 (3, 15) 4 (1, 10) 5 (2, 9) 5 (2, 9) 4 (2, 9) 5 (2, 9) 4 (2, 9)
post_p 0.82 (0.59, 0.96) 0.8 (0.6, 0.97) 0.7 (0.54, 0.9) 0.7 (0.54, 0.92) 0.73 (0.54, 0.9) 0.72 (0.54, 0.89) 0.72 (0.54, 0.9) 0.71 (0.53, 0.9)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.032 (0, 0.058) 0.033 (0, 0.058) 0.031 (0, 0.066) 0.029 (0, 0.069) 0.029 (0, 0.065) 0.029 (0, 0.071) 0.029 (0, 0.064) 0.027 (0, 0.071)
TEfus+ Platinum_CT count 18 18 18 18 18 18 18 18
time 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20)
n 4 (3, 9) 9 (5, 14) 4 (2, 8) 2 (1, 5) 3 (2, 7) 3 (0, 6) 3 (0, 4) 3 (1, 5)
post_p 0.63 (0.53, 0.74) 0.77 (0.63, 0.81) 0.64 (0.55, 0.8) 0.58 (0.53, 0.65) 0.63 (0.53, 0.79) 0.62 (0.55, 0.79) 0.61 (0.51, 0.79) 0.58 (0.52, 0.79)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.072 (0, 0.128) 0.061 (0.035, 0.104) 0 (0, 0.049) 0 (0, 0.071) 0.076 (0, 0.133) 0.068 (0, 0.135) 0 (0, 0.067) 0 (0, 0.069)
PARPi count 19 19 19 19 19 19 19 19
time 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30)
n 4 (3, 11) 15 (5, 23) 6 (3, 15) 3 (1, 6) 3 (2, 6) 5 (1, 8) 3 (2, 5) 2 (1, 8)
post_p 0.73 (0.55, 0.87) 0.81 (0.67, 0.9) 0.78 (0.58, 0.92) 0.67 (0.54, 0.92) 0.57 (0.52, 0.74) 0.6 (0.51, 0.83) 0.65 (0.55, 0.83) 0.58 (0.53, 0.87)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.077 (0.026, 0.117) 0.074 (0.048, 0.099) 0.027 (0, 0.045) 0.011 (0, 0.038) 0.096 (0.038, 0.134) 0.09 (0, 0.125) 0 (0, 0.039) 0.005 (0, 0.07)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all ARSi count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
time 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30)
n 26 (20, 46) 4 (0, 10) 20 (5, 30) 10 (5, 17) 6 (4, 8) 6 (2, 12) 4 (2, 8) 4 (2, 10) 8 (2, 11) 6 (1, 10) 6 (2, 8) 4 (1, 6) 4 (2, 5) 4 (2, 7) 4 (2, 8) 4 (1, 8)
post_p 0.32 (0.18, 0.45) 0.41 (0.39, 0.47) 0.3 (0.1, 0.38) 0.34 (0.24, 0.42) 0.37 (0.08, 0.44) 0.44 (0.33, 0.48) 0.3 (0.13, 0.38) 0.38 (0.25, 0.44) 0.43 (0.34, 0.46) 0.39 (0.32, 0.42) 0.44 (0.25, 0.46) 0.34 (0.26, 0.4) 0.3 (0.24, 0.38) 0.35 (0.18, 0.45) 0.24 (0.18, 0.45) 0.34 (0.15, 0.43)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.119 (0.108, 0.137) 0.161 (0.102, 0.242) 0.139 (0.128, 0.22) 0.139 (0.114, 0.169) 0.153 (0.088, 0.215) 0.1 (0.067, 0.607) 0.152 (0.115, 0.331) 0.138 (0.094, 0.209) 0.138 (0.107, 0.184) 0.152 (0.097, 0.212) 0.127 (0.11, 0.184) 0.195 (0.141, 0.592) 0.178 (0.123, 0.207) 0.143 (0.091, 0.541) 0.204 (0.07, 1.603) 0.111 (0.102, 0.353)
Taxane_CT count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
time 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34)
n 23 (21, 48) 4 (2, 11) 29 (11, 35) 10 (5, 19) 5 (3, 10) 6 (2, 11) 2 (2, 8) 3 (1, 8) 7 (3, 11) 8 (4, 8) 7 (4, 11) 4 (1, 6) 5 (3, 10) 6 (3, 10) 4 (1, 10) 3 (1, 6)
post_p 0.32 (0.09, 0.49) 0.4 (0.34, 0.46) 0.3 (0.18, 0.39) 0.35 (0.2, 0.44) 0.17 (0.09, 0.39) 0.3 (0.22, 0.43) 0.32 (0.23, 0.39) 0.37 (0.17, 0.41) 0.32 (0.18, 0.46) 0.24 (0.15, 0.39) 0.29 (0.16, 0.43) 0.38 (0.2, 0.49) 0.41 (0.14, 0.49) 0.35 (0.3, 0.45) 0.36 (0.28, 0.47) 0.44 (0.29, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.131 (0.112, 0.164) 0.146 (0.09, 0.366) 0.139 (0.119, 0.151) 0.154 (0.109, 0.179) 0.162 (0.1, 0.186) 0.122 (0.077, 0.216) 0.181 (0.136, 0.543) 0.157 (0.106, 0.496) 0.155 (0.107, 0.468) 0.169 (0.113, 0.347) 0.128 (0.084, 0.154) 0.26 (0.118, 0.445) 0.113 (0.082, 0.301) 0.099 (0.084, 0.21) 0.133 (0.095, 1.155) 0.094 (0.077, 0.148)
TP53- & AR- ARSi count 247 247 247 247
time 16 (9, 30) 16 (9, 30) 16 (9, 30) 16 (9, 30)
n 24 (15, 53) 5 (2, 12) 5 (2, 11) 5 (2, 11)
post_p 0.33 (0.13, 0.47) 0.42 (0.22, 0.49) 0.37 (0.15, 0.47) 0.38 (0.15, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.103, 0.171) 0.146 (0.094, 0.282) 0.13 (0.077, 0.259) 0.128 (0.075, 0.33)
Taxane_CT count 233 233 233 233
time 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28)
n 23 (15, 50) 5 (2, 11) 5 (2, 11) 5 (2, 10)
post_p 0.3 (0.11, 0.46) 0.41 (0.23, 0.48) 0.4 (0.15, 0.47) 0.4 (0.22, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.105, 0.174) 0.158 (0.101, 0.29) 0.135 (0.075, 0.272) 0.133 (0.074, 0.311)
Platinum_CT count 22 22 22 22
time 12 (8, 17) 12 (8, 17) 12 (8, 17) 12 (8, 17)
n 18 (14, 26) 4 (0, 6) 4 (1, 7) 4 (2, 8)
post_p 0.25 (0.13, 0.42) 0.37 (0.16, 0.47) 0.46 (0.38, 0.5) 0.4 (0.3, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.141 (0.114, 0.172) 0.208 (0.094, 0.474) 0.085 (0.003, 0.166) 0.113 (0.064, 0.21)
PARPi count 18 18 18 18
time 12 (9, 19) 12 (9, 19) 12 (9, 19) 12 (9, 19)
n 19 (14, 33) 5 (3, 7) 4 (1, 7) 4 (1, 9)
post_p 0.31 (0.13, 0.41) 0.39 (0.25, 0.47) 0.45 (0.43, 0.5) 0.43 (0.36, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.147 (0.115, 0.196) 0.183 (0.108, 0.34) 0.117 (0.066, 0.202) 0.123 (0.082, 0.358)
TP53+ ARSi count 74 74 74 74 74 74 74 74
time 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32)
n 16 (8, 32) 10 (5, 23) 4 (1, 8) 3 (1, 7) 5 (1, 9) 4 (0, 9) 3 (1, 7) 3 (1, 7)
post_p 0.34 (0.15, 0.48) 0.37 (0.14, 0.47) 0.37 (0.25, 0.48) 0.39 (0.21, 0.48) 0.41 (0.23, 0.49) 0.41 (0.27, 0.49) 0.41 (0.25, 0.48) 0.4 (0.22, 0.49)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.138 (0.097, 0.179) 0.14 (0.102, 0.235) 0.133 (0.079, 0.366) 0.14 (0.077, 0.484) 0.147 (0.09, 0.291) 0.16 (0.101, 0.448) 0.142 (0.078, 0.317) 0.126 (0.071, 0.397)
Taxane_CT count 74 74 74 74 74 74 74 74
time 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33)
n 20 (9, 34) 12 (5, 23) 4 (1, 8) 3 (1, 9) 5 (2, 11) 5 (1, 10) 4 (1, 8) 4 (1, 8)
post_p 0.33 (0.08, 0.48) 0.34 (0.18, 0.48) 0.38 (0.21, 0.48) 0.4 (0.19, 0.46) 0.36 (0.2, 0.48) 0.4 (0.23, 0.48) 0.37 (0.24, 0.46) 0.4 (0.19, 0.48)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.134 (0.103, 0.191) 0.132 (0.105, 0.215) 0.148 (0.079, 0.348) 0.131 (0.069, 0.43) 0.167 (0.11, 0.313) 0.157 (0.102, 0.356) 0.133 (0.068, 0.291) 0.129 (0.076, 0.225)
Platinum_CT count 3 3 3 3 3 3 3 3
time 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17)
n 11 (10, 14) 7 (4, 13) 3 (1, 5) 3 (1, 5) 2 (1, 4) 3 (1, 3) 2 (1, 2) 0 (0, 3)
post_p 0.36 (0.19, 0.44) 0.16 (0.11, 0.43) 0.46 (0.45, 0.48) 0.44 (0.38, 0.47) 0.46 (0.38, 0.49) 0.39 (0.34, 0.46) 0.42 (0.4, 0.42) 0.49 (0.49, 0.49)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.166 (0.14, 0.209) 0.205 (0.086, 0.274) 0.116 (0.062, 0.177) 0.075 (0.069, 0.707) 0.182 (0.036, 0.21) 0.297 (0.242, 0.412) 0.202 (0.105, 4.715) 0.242 (0.242, 0.242)
PARPi count 2 2 2 2 2 2 2 2
time 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16)
n 12 (9, 16) 8 (6, 10) 0 (0, 1) 4 (3, 5) 4 (3, 5) 2 (1, 2) 2 (0, 3) 2 (1, 3)
post_p 0.3 (0.25, 0.34) 0.35 (0.27, 0.43) 0.48 (0.48, 0.48) 0.49 (0.49, 0.5) 0.43 (0.42, 0.43) 0.46 (0.43, 0.48) 0.46 (0.46, 0.46) 0.42 (0.38, 0.45)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.142 (0.137, 0.147) 0.132 (0.117, 0.147) 0 (0, 0) 0.084 (0.06, 0.108) 0.202 (0.13, 0.273) 0.392 (0.161, 0.622) 0.076 (0.076, 0.076) 0.165 (0.099, 0.231)
HRD+ ARSi count 214 214 214 214 214 214 214 214
time 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32)
n 6 (2, 12) 6 (3, 12) 4 (1, 8) 4 (1, 8) 5 (2, 9) 4 (2, 8) 4 (2, 8) 4 (2, 8)
post_p 0.33 (0.13, 0.47) 0.34 (0.14, 0.47) 0.37 (0.18, 0.48) 0.39 (0.21, 0.48) 0.36 (0.17, 0.48) 0.38 (0.18, 0.46) 0.38 (0.18, 0.48) 0.4 (0.21, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.122 (0.081, 0.241) 0.127 (0.078, 0.258) 0.144 (0.075, 0.357) 0.139 (0.071, 0.314) 0.136 (0.073, 0.382) 0.153 (0.073, 0.312) 0.13 (0.073, 0.324) 0.136 (0.076, 0.305)
Taxane_CT count 197 197 197 197 197 197 197 197
time 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32)
n 6 (3, 13) 6 (3, 12) 5 (2, 9) 5 (2, 9) 5 (2, 9) 4 (2, 9) 5 (2, 9) 4 (2, 8)
post_p 0.33 (0.1, 0.46) 0.32 (0.13, 0.47) 0.36 (0.18, 0.48) 0.38 (0.2, 0.48) 0.38 (0.19, 0.47) 0.38 (0.17, 0.48) 0.37 (0.18, 0.46) 0.37 (0.16, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.123 (0.079, 0.229) 0.124 (0.078, 0.272) 0.137 (0.078, 0.269) 0.135 (0.076, 0.288) 0.125 (0.074, 0.343) 0.133 (0.077, 0.313) 0.133 (0.084, 0.294) 0.125 (0.078, 0.328)
TEfus+ ARSi count 65 65 65 65 65 65 65 65
time 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34)
n 5 (2, 12) 13 (7, 23) 5 (2, 12) 3 (1, 8) 6 (3, 10) 5 (1, 11) 4 (1, 7) 4 (1, 8)
post_p 0.36 (0.18, 0.48) 0.34 (0.15, 0.47) 0.33 (0.12, 0.44) 0.38 (0.19, 0.46) 0.41 (0.15, 0.49) 0.39 (0.22, 0.48) 0.34 (0.12, 0.48) 0.42 (0.23, 0.49)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.163 (0.103, 0.309) 0.137 (0.103, 0.205) 0.134 (0.079, 0.292) 0.13 (0.081, 0.286) 0.145 (0.1, 0.32) 0.153 (0.095, 0.257) 0.172 (0.073, 0.481) 0.119 (0.074, 0.255)
Taxane_CT count 67 67 67 67 67 67 67 67
time 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31)
n 5 (2, 12) 13 (8, 22) 6 (2, 10) 4 (1, 8) 5 (2, 9) 5 (2, 8) 4 (1, 7) 4 (2, 8)
post_p 0.37 (0.19, 0.5) 0.35 (0.1, 0.47) 0.31 (0.16, 0.47) 0.38 (0.14, 0.47) 0.42 (0.2, 0.48) 0.41 (0.16, 0.49) 0.38 (0.2, 0.48) 0.38 (0.17, 0.48)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.152 (0.098, 0.296) 0.138 (0.102, 0.194) 0.135 (0.078, 0.342) 0.138 (0.068, 0.465) 0.15 (0.097, 0.329) 0.157 (0.095, 0.361) 0.117 (0.063, 0.246) 0.119 (0.074, 0.287)
PARPi count 1 1 1 1 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 1 (1, 1) 6 (6, 6) 0 (0, 0) 3 (3, 3) 6 (6, 6) 5 (5, 5) 1 (1, 1) 3 (3, 3)
post_p 0.46 (0.46, 0.46) 0.48 (0.48, 0.48) NA (NA, NA) 0.4 (0.4, 0.4) 0.17 (0.17, 0.17) 0.13 (0.13, 0.13) 0.37 (0.37, 0.37) 0.48 (0.48, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.151 (0.151, 0.151) 0.118 (0.118, 0.118) NA (NA, NA) 0.151 (0.151, 0.151) 0.223 (0.223, 0.223) 0.361 (0.361, 0.361) 13.589 (13.589, 13.589) 0.041 (0.041, 0.041)