Simulation scenario 9, CR phase

Setting description

Equal randomization: Platinum_CT and PARPi more effective in the HRD+ biomarker signature (cfr scen 6)

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.091, shape = 1.05	scale = 0.091, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.8, median = 7.7	mean = 10.8, median = 7.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.23, hr = 0.81	af = 1.23, hr = 0.81
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.093, shape = 1.05	scale = 0.093, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.5, median = 7.6	mean = 10.5, median = 7.6
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.2, hr = 0.83	af = 1.2, hr = 0.83
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.092, shape = 1.05	scale = 0.092, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 10.7, median = 7.7	mean = 10.7, median = 7.7
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.21, hr = 0.82	af = 1.21, hr = 0.82
HRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.084, shape = 1.05	scale = 0.084, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 11.7, median = 8.4	mean = 11.7, median = 8.4
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1.33, hr = 0.74	af = 1.33, hr = 0.74

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.037, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 26.6, median = 19.1
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 3.03, hr = 0.31

Errors and power

graduation (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 0 2 13 19 TP53- & AR- 12 12 140 119 TP53+ 1 1 25 17 HRD+ 0 0 291 301 TEfus+ 0 0 18 19

ARSi Taxane_CT Platinum_CT PARPi all 0.000 0.004 0.026 0.038 TP53- & AR- 0.024 0.024 0.280 0.238 TP53+ 0.002 0.002 0.050 0.034 HRD+ 0.000 0.000 0.582 0.602 TEfus+ 0.000 0.000 0.036 0.038

futility (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 6 7 0 0 TP53- & AR- 247 233 22 18 TP53+ 74 74 3 2 HRD+ 214 197 0 0 TEfus+ 65 67 0 1

ARSi Taxane_CT Platinum_CT PARPi all 0.012 0.014 0.000 0.000 TP53- & AR- 0.494 0.466 0.044 0.036 TP53+ 0.148 0.148 0.006 0.004 HRD+ 0.428 0.394 0.000 0.000 TEfus+ 0.130 0.134 0.000 0.002

max sample size (counts and proportions):

ARSi Taxane_CT Platinum_CT PARPi all 0 0 0 0 TP53- & AR- 16 12 18 14 TP53+ 1 6 8 12 HRD+ 0 0 0 0 TEfus+ 0 0 0 0

ARSi Taxane_CT Platinum_CT PARPi all 0.000 0.000 0.000 0.000 TP53- & AR- 0.032 0.024 0.036 0.028 TP53+ 0.002 0.012 0.016 0.024 HRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.000

Errors & power

The overall error was 0.268.
The corresponding errors separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.026       0.030       0.134       0.106 

The overall power was 0.832.
The corresponding power separate for the different treatments were:

       ARSi   Taxane_CT Platinum_CT       PARPi 
      0.000       0.000       0.582       0.602 

Median results at the end of the trial

By signature:

signature	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
all	graduation	0	0	2	13	19
	futility	0	6	7	0	0
	max_n	0	0	0	0	0
	n	280 (245, 324)	208 (148, 275)	213 (144, 282)	232 (159, 287)	231 (171, 286)
	n_unique	257 (224, 296)	194 (136, 257)	198 (134, 262)	214 (145, 265)	213 (155, 262)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	22 (15, 30)	27 (5, 34)	10 (4, 33)	27 (12, 34)
	post_p	NA (NA, NA)	0.4 (0.07, 0.86)	0.43 (0.07, 0.84)	1 (0.95, 1)	1 (0.93, 1)
	rate	0.111 (0.102, 0.122)	0.113 (0.102, 0.126)	0.113 (0.103, 0.126)	0.082 (0.073, 0.091)	0.081 (0.072, 0.092)
TP53- & AR-	graduation	0	12	12	140	119
	futility	0	247	233	22	18
	max_n	0	16	12	18	14
	n	120 (95, 149)	82 (27, 122)	83 (27, 123)	96 (29, 130)	96 (32, 129)
	n_unique	111 (87, 139)	75 (25, 114)	78 (26, 116)	89 (27, 122)	89 (29, 120)
	time_trial	36 (36, 36)	32 (11, 36)	36 (11, 36)	36 (12, 36)	36 (13, 36)
	time_stop	NA (NA, NA)	15 (9, 30)	14 (10, 28)	15 (10, 32)	15 (10, 29)
	post_p	NA (NA, NA)	0.38 (0.08, 0.83)	0.39 (0.07, 0.85)	0.95 (0.67, 1)	0.94 (0.61, 1)
	rate	0.111 (0.098, 0.129)	0.115 (0.098, 0.143)	0.114 (0.097, 0.144)	0.084 (0.068, 0.101)	0.084 (0.069, 0.102)
TP53+	graduation	0	1	1	25	17
	futility	0	74	74	3	2
	max_n	0	1	6	8	12
	n	119 (102, 142)	105 (64, 125)	104 (68, 129)	104 (80, 127)	105 (80, 129)
	n_unique	109 (92, 130)	97 (59, 115)	96 (63, 119)	95 (73, 117)	97 (74, 118)
	time_trial	36 (36, 36)	36 (24, 36)	36 (27, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	18 (8, 32)	19 (9, 33)	12 (8, 23)	18 (10, 32)
	post_p	NA (NA, NA)	0.41 (0.07, 0.83)	0.42 (0.07, 0.8)	0.96 (0.66, 1)	0.96 (0.75, 1)
	rate	0.111 (0.098, 0.129)	0.113 (0.098, 0.133)	0.114 (0.1, 0.133)	0.084 (0.07, 0.099)	0.082 (0.07, 0.097)
HRD+	graduation	0	0	0	291	301
	futility	0	214	197	0	0
	max_n	0	0	0	0	0
	n	84 (67, 105)	56 (28, 88)	59 (30, 91)	59 (26, 88)	56 (27, 87)
	n_unique	78 (61, 98)	51 (25, 80)	54 (28, 85)	53 (24, 81)	52 (25, 79)
	time_trial	36 (36, 36)	36 (17, 36)	36 (19, 36)	33 (15, 36)	32 (16, 36)
	time_stop	NA (NA, NA)	21 (14, 32)	22 (16, 32)	24 (14, 34)	23 (14, 33)
	post_p	NA (NA, NA)	0.28 (0.05, 0.72)	0.26 (0.05, 0.72)	1 (1, 1)	1 (1, 1)
	rate	0.112 (0.095, 0.131)	0.113 (0.094, 0.145)	0.114 (0.095, 0.139)	0.036 (0.028, 0.046)	0.036 (0.028, 0.045)
TEfus+	graduation	0	0	0	18	19
	futility	0	65	67	0	1
	max_n	0	0	0	0	0
	n	104 (86, 125)	79 (49, 104)	80 (48, 109)	86 (58, 108)	83 (60, 108)
	n_unique	95 (79, 113)	72 (44, 97)	74 (43, 100)	78 (52, 99)	76 (54, 98)
	time_trial	36 (36, 36)	36 (29, 36)	36 (28, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	21 (12, 34)	22 (13, 31)	12 (10, 20)	18 (11, 30)
	post_p	NA (NA, NA)	0.43 (0.06, 0.82)	0.38 (0.07, 0.82)	0.98 (0.8, 1)	0.99 (0.86, 1)
	rate	0.112 (0.096, 0.127)	0.113 (0.096, 0.135)	0.113 (0.097, 0.132)	0.074 (0.062, 0.091)	0.073 (0.06, 0.087)

By subgroup combinations:

subtype	var	Control	ARSi	Taxane_CT	Platinum_CT	PARPi
—-	graduation	0	259	248	170	144
	futility	0	0	0	0	0
	max_n	0	16	12	18	14
	n	73 (56, 94)	52 (17, 76)	52 (17, 77)	61 (20, 84)	63 (20, 83)
	n_unique	67 (51, 88)	48 (16, 72)	50 (16, 73)	57 (18, 80)	58 (19, 79)
	post_p	NA (NA, NA)	0.46 (0.09, 0.84)	0.46 (0.1, 0.86)	0.52 (0.14, 0.89)	0.51 (0.11, 0.89)
	rate	0.112 (0.094, 0.133)	0.116 (0.095, 0.147)	0.113 (0.094, 0.149)	0.112 (0.089, 0.135)	0.112 (0.092, 0.135)
—+	graduation	0	280	261	181	151
	futility	0	0	0	0	0
	max_n	0	16	12	18	14
	n	15 (9, 22)	9 (3, 17)	9 (3, 18)	12 (3, 19)	12 (4, 20)
	n_unique	14 (8, 20)	8 (2, 16)	8 (3, 17)	11 (3, 17)	11 (3, 18)
	post_p	NA (NA, NA)	0.44 (0.2, 0.83)	0.47 (0.19, 0.81)	0.49 (0.16, 0.81)	0.5 (0.17, 0.81)
	rate	0.112 (0.077, 0.161)	0.119 (0.074, 0.214)	0.12 (0.075, 0.211)	0.117 (0.072, 0.185)	0.114 (0.074, 0.178)
–+-	graduation	0	75	77	39	37
	futility	0	0	0	0	0
	max_n	0	1	6	8	12
	n	37 (29, 47)	34 (21, 43)	35 (23, 44)	36 (24, 44)	36 (27, 45)
	n_unique	34 (26, 44)	32 (20, 40)	32 (22, 41)	33 (22, 41)	33 (25, 42)
	post_p	NA (NA, NA)	0.48 (0.14, 0.88)	0.48 (0.14, 0.82)	0.48 (0.13, 0.85)	0.51 (0.14, 0.89)
	rate	0.112 (0.09, 0.141)	0.113 (0.088, 0.148)	0.115 (0.092, 0.147)	0.114 (0.09, 0.144)	0.113 (0.088, 0.145)
–++	graduation	0	112	122	51	49
	futility	0	0	0	0	0
	max_n	0	1	6	8	12
	n	25 (19, 34)	23 (11, 31)	23 (11, 30)	24 (14, 33)	24 (16, 32)
	n_unique	23 (17, 31)	21 (10, 29)	21 (10, 29)	22 (13, 30)	22 (14, 29)
	post_p	NA (NA, NA)	0.48 (0.17, 0.87)	0.48 (0.16, 0.83)	0.5 (0.14, 0.83)	0.52 (0.18, 0.86)
	rate	0.113 (0.085, 0.149)	0.114 (0.084, 0.159)	0.116 (0.085, 0.158)	0.113 (0.083, 0.153)	0.111 (0.084, 0.146)
-+–	graduation	0	345	336	357	359
	futility	0	0	0	0	0
	max_n	0	16	12	16	12
	n	16 (10, 23)	8 (3, 19)	8 (3, 18)	9 (3, 19)	10 (3, 18)
	n_unique	14 (9, 22)	7 (2, 18)	8 (2, 17)	9 (3, 17)	9 (3, 16)
	post_p	NA (NA, NA)	0.3 (0.09, 0.59)	0.31 (0.1, 0.61)	0.92 (0.69, 0.99)	0.92 (0.63, 1)
	rate	0.11 (0.08, 0.163)	0.12 (0.078, 0.216)	0.119 (0.077, 0.204)	0.036 (0.016, 0.065)	0.037 (0.018, 0.066)
-+-+	graduation	0	352	340	362	362
	futility	0	0	0	0	0
	max_n	0	16	12	16	12
	n	16 (10, 23)	8 (3, 18)	8 (3, 18)	10 (3, 19)	9 (3, 18)
	n_unique	15 (8, 21)	7 (2, 16)	7 (2, 17)	9 (2, 18)	8 (3, 17)
	post_p	NA (NA, NA)	0.32 (0.12, 0.61)	0.31 (0.1, 0.62)	0.92 (0.67, 0.99)	0.92 (0.66, 0.99)
	rate	0.113 (0.074, 0.168)	0.117 (0.075, 0.215)	0.119 (0.077, 0.226)	0.037 (0.019, 0.066)	0.037 (0.017, 0.065)
-++-	graduation	0	240	233	307	311
	futility	0	0	0	0	0
	max_n	0	1	6	7	12
	n	9 (5, 13)	6 (2, 12)	6 (2, 12)	6 (2, 11)	5 (2, 11)
	n_unique	8 (4, 13)	6 (2, 11)	6 (2, 11)	5 (2, 11)	5 (1, 10)
	post_p	NA (NA, NA)	0.35 (0.11, 0.59)	0.34 (0.13, 0.63)	0.83 (0.57, 0.97)	0.82 (0.55, 0.96)
	rate	0.116 (0.07, 0.197)	0.122 (0.069, 0.253)	0.118 (0.066, 0.221)	0.037 (0.013, 0.077)	0.037 (0.012, 0.08)
-+++	graduation	0	254	253	313	315
	futility	0	0	0	0	0
	max_n	0	1	6	7	12
	n	9 (5, 14)	6 (2, 11)	7 (2, 12)	6 (2, 11)	6 (2, 11)
	n_unique	8 (4, 13)	5 (2, 11)	6 (2, 11)	5 (1, 10)	5 (2, 10)
	post_p	NA (NA, NA)	0.34 (0.14, 0.63)	0.34 (0.15, 0.6)	0.8 (0.54, 0.95)	0.81 (0.55, 0.97)
	rate	0.114 (0.063, 0.191)	0.121 (0.066, 0.256)	0.117 (0.068, 0.229)	0.039 (0.015, 0.078)	0.036 (0.012, 0.076)
+—	graduation	0	6	9	13	19
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (8, 17)	12 (8, 17)	12 (8, 16)	12 (7, 17)	12 (8, 17)
	n_unique	10 (6, 15)	11 (7, 16)	11 (7, 15)	11 (7, 15)	11 (7, 15)
	post_p	NA (NA, NA)	0.5 (0.17, 0.84)	0.48 (0.17, 0.84)	0.5 (0.18, 0.82)	0.52 (0.19, 0.81)
	rate	0.114 (0.074, 0.18)	0.114 (0.072, 0.176)	0.118 (0.076, 0.18)	0.113 (0.075, 0.173)	0.112 (0.077, 0.172)
+–+	graduation	0	66	69	27	32
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	10 (6, 14)	9 (5, 14)	9 (5, 14)	9 (5, 13)	9 (5, 14)
	n_unique	9 (5, 13)	8 (5, 13)	8 (4, 13)	9 (5, 13)	8 (4, 13)
	post_p	NA (NA, NA)	0.48 (0.2, 0.81)	0.48 (0.19, 0.84)	0.48 (0.19, 0.8)	0.5 (0.19, 0.81)
	rate	0.116 (0.069, 0.189)	0.117 (0.072, 0.195)	0.119 (0.068, 0.205)	0.119 (0.074, 0.186)	0.112 (0.071, 0.195)
+-+-	graduation	0	75	77	39	37
	futility	0	0	0	0	0
	max_n	0	1	6	8	12
	n	10 (6, 15)	9 (4, 14)	9 (5, 13)	10 (5, 14)	10 (5, 14)
	n_unique	9 (5, 13)	8 (4, 12)	8 (4, 12)	9 (4, 13)	9 (5, 13)
	post_p	NA (NA, NA)	0.47 (0.17, 0.79)	0.5 (0.18, 0.78)	0.49 (0.2, 0.82)	0.5 (0.21, 0.83)
	rate	0.112 (0.07, 0.184)	0.12 (0.072, 0.198)	0.114 (0.075, 0.195)	0.115 (0.069, 0.18)	0.114 (0.072, 0.182)
+-++	graduation	0	112	122	51	49
	futility	0	0	0	0	0
	max_n	0	1	6	8	12
	n	10 (6, 15)	9 (4, 14)	9 (4, 14)	9 (5, 14)	9 (5, 15)
	n_unique	9 (6, 14)	8 (3, 13)	8 (3, 13)	8 (4, 13)	9 (4, 13)
	post_p	NA (NA, NA)	0.47 (0.16, 0.8)	0.5 (0.19, 0.81)	0.49 (0.19, 0.8)	0.53 (0.21, 0.82)
	rate	0.114 (0.069, 0.185)	0.12 (0.073, 0.212)	0.113 (0.072, 0.218)	0.117 (0.069, 0.194)	0.108 (0.07, 0.18)
++–	graduation	0	215	199	299	308
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	8 (5, 13)	7 (2, 11)	7 (3, 12)	6 (2, 11)	6 (2, 11)
	n_unique	8 (5, 12)	6 (2, 10)	6 (2, 11)	5 (2, 10)	5 (2, 10)
	post_p	NA (NA, NA)	0.33 (0.13, 0.59)	0.34 (0.14, 0.59)	0.82 (0.55, 0.97)	0.82 (0.58, 0.97)
	rate	0.115 (0.068, 0.191)	0.12 (0.069, 0.217)	0.119 (0.063, 0.252)	0.037 (0.013, 0.08)	0.035 (0.013, 0.077)
++-+	graduation	0	232	226	305	313
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	9 (5, 13)	6 (2, 11)	7 (2, 12)	6 (2, 11)	5 (2, 10)
	n_unique	8 (4, 12)	5 (2, 10)	6 (2, 11)	5 (2, 10)	5 (2, 10)
	post_p	NA (NA, NA)	0.33 (0.12, 0.61)	0.34 (0.11, 0.6)	0.8 (0.55, 0.97)	0.81 (0.57, 0.96)
	rate	0.112 (0.068, 0.192)	0.124 (0.07, 0.265)	0.115 (0.068, 0.24)	0.037 (0.01, 0.073)	0.035 (0.012, 0.072)
+++-	graduation	0	240	233	307	311
	futility	0	0	0	0	0
	max_n	0	1	6	7	12
	n	9 (5, 13)	6 (2, 11)	7 (2, 12)	6 (2, 11)	6 (2, 11)
	n_unique	8 (4, 13)	6 (2, 10)	6 (2, 11)	5 (2, 10)	5 (2, 10)
	post_p	NA (NA, NA)	0.35 (0.15, 0.63)	0.35 (0.12, 0.6)	0.82 (0.57, 0.96)	0.83 (0.53, 0.96)
	rate	0.119 (0.069, 0.197)	0.112 (0.065, 0.244)	0.116 (0.068, 0.225)	0.036 (0.014, 0.076)	0.037 (0.014, 0.079)
++++	graduation	0	254	253	313	315
	futility	0	0	0	0	0
	max_n	0	1	6	7	12
	n	9 (5, 14)	6 (2, 12)	6 (2, 12)	6 (2, 11)	6 (2, 11)
	n_unique	8 (4, 13)	5 (2, 11)	6 (2, 11)	5 (1, 10)	5 (2, 10)
	post_p	NA (NA, NA)	0.35 (0.14, 0.6)	0.32 (0.13, 0.59)	0.81 (0.54, 0.96)	0.82 (0.55, 0.97)
	rate	0.114 (0.066, 0.19)	0.121 (0.066, 0.235)	0.123 (0.075, 0.244)	0.038 (0.014, 0.075)	0.036 (0.013, 0.074)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count		2	13	19
	time_stop		5 (5, 5)	10 (4, 33)	27 (12, 34)
	n_trt		32 (28, 36)	67 (25, 150)	155 (87, 225)
	n_control		34 (24, 44)	70 (31, 265)	203 (82, 275)
	post_p		0.9 (0.88, 0.92)	1 (0.92, 1)	1 (0.97, 1)
	order		1 (1, 1)	1 (1, 5)	3 (1, 5)
TP53- & AR-	count	12	12	140	119
	time_stop	10 (8, 14)	14 (10, 16)	16 (10, 33)	17 (10, 30)
	n_trt	26 (25, 31)	32 (25, 42)	44 (26, 95)	41 (26, 94)
	n_control	24 (22, 38)	38 (30, 48)	47 (25, 104)	48 (26, 97)
	post_p	0.9 (0.86, 0.97)	0.94 (0.89, 0.98)	0.97 (0.89, 1)	0.96 (0.89, 1)
	order	1 (1, 1.9)	1 (1, 2)	1 (1, 3)	1 (1, 3)
TP53+	count	1	1	25	17
	time_stop	9 (9, 9)	8 (8, 8)	11 (8, 24)	21 (10, 32)
	n_trt	32 (32, 32)	25 (25, 25)	34 (25, 60)	64 (27, 103)
	n_control	23 (23, 23)	15 (15, 15)	32 (22, 72)	71 (33, 113)
	post_p	0.92 (0.92, 0.92)	0.99 (0.99, 0.99)	0.98 (0.9, 1)	1 (0.95, 1)
	order	1 (1, 1)	1 (1, 1)	1 (1, 3)	2 (1, 3.4)
HRD+	count			291	301
	time_stop			24 (14, 34)	23 (14, 33)
	n_trt			42 (26, 76)	43 (26, 74)
	n_control			51 (25, 82)	47 (25, 79)
	post_p			1 (0.98, 1)	1 (0.99, 1)
	order			2 (1, 3)	2 (1, 3)
TEfus+	count			18	19
	time_stop			12 (10, 20)	20 (11, 30)
	n_trt			30 (26, 51)	43 (25, 72)
	n_control			30 (24, 52)	49 (25, 85)
	post_p			0.99 (0.91, 1)	0.99 (0.97, 1)
	order			1.5 (1, 4)	2 (1, 4)

Futility:

signature	var	ARSi	Taxane_CT	Platinum_CT	PARPi
all	count	6	7
	time_stop	22 (15, 30)	31 (23, 34)
	n_trt	110 (77, 188)	132 (98, 188)
	n_control	157 (110, 220)	227 (180, 265)
	post_p	0.01 (0.01, 0.2)	0.01 (0, 0.1)
	order	3.5 (2.5, 5)	5 (3.6, 6)
TP53- & AR-	count	247	233	22	18
	time_stop	16 (9, 30)	14 (10, 28)	12 (8, 17)	12 (9, 19)
	n_trt	40 (26, 86)	37 (26, 80)	30 (25, 40)	29 (26, 53)
	n_control	44 (23, 87)	38 (23, 86)	32 (17, 43)	34 (20, 54)
	post_p	0.18 (0.05, 0.28)	0.16 (0.04, 0.27)	0.13 (0.05, 0.23)	0.17 (0.05, 0.26)
	order	1 (1, 3)	1 (1, 3)	1 (1, 2)	1 (1, 2)
TP53+	count	74	74	3	2
	time_stop	18 (8, 32)	20 (10, 33)	12 (9, 17)	12 (7, 16)
	n_trt	54 (26, 87)	58 (27, 101)	28 (27, 42)	34 (27, 41)
	n_control	54 (24, 102)	56 (29, 107)	43 (26, 61)	36 (21, 52)
	post_p	0.08 (0.02, 0.24)	0.08 (0.01, 0.23)	0.06 (0.02, 0.13)	0.13 (0.13, 0.14)
	order	2 (1, 4.7)	2 (1, 4)	1 (1, 1.8)	1 (1, 1)
HRD+	count	214	197
	time_stop	21 (14, 32)	22 (16, 32)
	n_trt	36 (26, 60)	39 (27, 68)
	n_control	43 (24, 70)	47 (28, 77)
	post_p	0.1 (0.01, 0.24)	0.09 (0.01, 0.21)
	order	2 (1, 4)	2 (1, 4)
TEfus+	count	65	67		1
	time_stop	21 (12, 34)	22 (13, 31)		15 (15, 15)
	n_trt	44 (27, 77)	49 (29, 76)		25 (25, 25)
	n_control	53 (25, 99)	60 (31, 97)		37 (37, 37)
	post_p	0.08 (0.01, 0.19)	0.07 (0.01, 0.21)		0.02 (0.02, 0.02)
	order	3 (1, 4.6)	3 (1, 5)		1 (1, 1)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Taxane_CT	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)	5 (5, 5)
		n	12 (10, 13)	0 (0, 1)	5 (3, 7)	2 (1, 4)	1 (0, 2)	1 (0, 2)	0 (0, 0)	1 (0, 2)	2 (0, 3)	2 (1, 3)	2 (2, 2)	0 (0, 1)	2 (2, 2)	0 (0, 1)	1 (0, 2)	0 (0, 0)
		post_p	0.6 (0.58, 0.62)	NA (NA, NA)	0.57 (0.56, 0.57)	0.57 (0.56, 0.59)	0.6 (0.6, 0.6)	0.53 (0.53, 0.53)	NA (NA, NA)	0.5 (0.5, 0.5)	0.62 (0.62, 0.62)	0.53 (0.52, 0.53)	0.51 (0.51, 0.51)	0.53 (0.53, 0.53)	0.57 (0.57, 0.57)	0.54 (0.54, 0.54)	0.58 (0.58, 0.58)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.044 (0.009, 0.078)	0 (0, 0)	0.045 (0.009, 0.08)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0.177 (0.177, 0.177)	0 (0, 0)	0.066 (0.013, 0.119)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)
	Platinum_CT	count	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13
		time	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)	10 (4, 33)
		n	14 (6, 39)	4 (0, 10)	13 (4, 29)	8 (1, 18)	3 (2, 8)	3 (1, 8)	2 (1, 7)	2 (1, 3)	4 (1, 13)	3 (1, 7)	3 (0, 7)	3 (1, 9)	2 (0, 5)	2 (1, 4)	2 (0, 8)	3 (0, 5)
		post_p	0.7 (0.52, 0.93)	0.59 (0.53, 0.8)	0.59 (0.53, 0.76)	0.64 (0.51, 0.79)	0.59 (0.52, 0.87)	0.69 (0.52, 0.9)	0.59 (0.53, 0.74)	0.55 (0.51, 0.82)	0.62 (0.52, 0.75)	0.65 (0.51, 0.76)	0.56 (0.52, 0.83)	0.56 (0.52, 0.75)	0.53 (0.51, 0.68)	0.64 (0.52, 0.74)	0.62 (0.52, 0.81)	0.63 (0.54, 0.91)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.087 (0.035, 0.127)	0.077 (0, 0.106)	0.095 (0, 0.123)	0.08 (0, 0.123)	0.007 (0, 0.069)	0.02 (0, 0.045)	0 (0, 0.059)	0 (0, 0.074)	0.062 (0, 0.126)	0.031 (0, 0.114)	0.052 (0, 0.13)	0.07 (0, 0.129)	0.038 (0, 0.073)	0 (0, 0.057)	0 (0, 0.058)	0.014 (0, 0.06)
	PARPi	count	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19	19
		time	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)	27 (12, 34)
		n	36 (16, 59)	5 (2, 10)	26 (12, 32)	14 (7, 23)	6 (2, 14)	6 (2, 12)	3 (0, 8)	3 (1, 6)	9 (3, 12)	5 (0, 8)	9 (2, 14)	6 (0, 9)	3 (1, 8)	3 (1, 6)	5 (1, 9)	4 (2, 8)
		post_p	0.65 (0.54, 0.87)	0.72 (0.54, 0.8)	0.62 (0.55, 0.86)	0.69 (0.55, 0.88)	0.88 (0.55, 0.97)	0.86 (0.62, 0.99)	0.76 (0.55, 0.88)	0.65 (0.56, 0.9)	0.6 (0.51, 0.85)	0.62 (0.53, 0.82)	0.58 (0.51, 0.67)	0.64 (0.54, 0.8)	0.74 (0.56, 0.91)	0.65 (0.58, 0.83)	0.72 (0.57, 0.93)	0.75 (0.58, 0.92)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.103 (0.072, 0.122)	0.079 (0.048, 0.171)	0.093 (0.072, 0.118)	0.095 (0.078, 0.11)	0.042 (0, 0.059)	0.026 (0, 0.046)	0.04 (0, 0.052)	0.042 (0, 0.066)	0.093 (0.048, 0.13)	0.094 (0.072, 0.122)	0.106 (0.063, 0.132)	0.086 (0.055, 0.119)	0.033 (0, 0.061)	0.025 (0, 0.05)	0.037 (0, 0.065)	0.018 (0, 0.048)
TP53- & AR-	ARSi	count	12	12			12	12
		time	10 (8, 14)	10 (8, 14)			10 (8, 14)	10 (8, 14)
		n	19 (15, 22)	3 (2, 5)			2 (1, 4)	4 (1, 5)
		post_p	0.82 (0.75, 0.93)	0.59 (0.53, 0.72)			0.54 (0.52, 0.63)	0.58 (0.52, 0.69)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.079 (0.055, 0.097)	0 (0, 0.174)			0 (0, 0.043)	0.056 (0, 0.113)
	Taxane_CT	count	12	12			12	12
		time	14 (10, 16)	14 (10, 16)			14 (10, 16)	14 (10, 16)
		n	20 (18, 26)	4 (1, 6)			4 (2, 9)	4 (1, 6)
		post_p	0.85 (0.76, 0.97)	0.58 (0.52, 0.75)			0.56 (0.5, 0.82)	0.56 (0.54, 0.75)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.071 (0.044, 0.101)	0.081 (0, 0.112)			0.05 (0, 0.134)	0.059 (0, 0.089)
	Platinum_CT	count	140	140			140	140
		time	16 (10, 33)	16 (10, 33)			16 (10, 33)	16 (10, 33)
		n	28 (17, 59)	5 (2, 13)			5 (2, 15)	5 (2, 12)
		post_p	0.78 (0.71, 0.93)	0.68 (0.52, 0.81)			0.73 (0.55, 0.96)	0.73 (0.55, 0.96)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.086 (0.052, 0.107)	0.071 (0, 0.127)			0.025 (0, 0.056)	0.02 (0, 0.054)
	PARPi	count	119	119			119	119
		time	17 (10, 30)	17 (10, 30)			17 (10, 30)	17 (10, 30)
		n	27 (16, 57)	5 (2, 12)			5 (2, 14)	5 (2, 13)
		post_p	0.75 (0.71, 0.88)	0.66 (0.54, 0.84)			0.75 (0.54, 0.95)	0.72 (0.53, 0.94)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.092 (0.061, 0.112)	0.076 (0, 0.143)			0.027 (0, 0.063)	0.027 (0, 0.066)
TP53+	ARSi	count			1	1			1	1			1	1			1	1
		time			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)
		n			5 (5, 5)	8 (8, 8)			3 (3, 3)	5 (5, 5)			1 (1, 1)	4 (4, 4)			3 (3, 3)	3 (3, 3)
		post_p			0.5 (0.5, 0.5)	0.88 (0.88, 0.88)			0.5 (0.5, 0.5)	0.5 (0.5, 0.5)			0.51 (0.51, 0.51)	0.64 (0.64, 0.64)			NA (NA, NA)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.098 (0.098, 0.098)	0.068 (0.068, 0.068)			0.107 (0.107, 0.107)	0.044 (0.044, 0.044)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0.182 (0.182, 0.182)
	Taxane_CT	count			1	1			1	1			1	1			1	1
		time			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)
		n			11 (11, 11)	4 (4, 4)			4 (4, 4)	1 (1, 1)			0 (0, 0)	2 (2, 2)			0 (0, 0)	3 (3, 3)
		post_p			0.89 (0.89, 0.89)	0.65 (0.65, 0.65)			0.6 (0.6, 0.6)	NA (NA, NA)			NA (NA, NA)	0.57 (0.57, 0.57)			NA (NA, NA)	0.56 (0.56, 0.56)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)			NA (NA, NA)	0 (0, 0)			NA (NA, NA)	0 (0, 0)
	Platinum_CT	count			25	25			25	25			25	25			25	25
		time			11 (8, 24)	11 (8, 24)			11 (8, 24)	11 (8, 24)			11 (8, 24)	11 (8, 24)			11 (8, 24)	11 (8, 24)
		n			13 (8, 27)	8 (4, 16)			3 (1, 4)	2 (0, 5)			3 (0, 5)	2 (1, 5)			2 (0, 4)	2 (0, 4)
		post_p			0.76 (0.71, 0.87)	0.73 (0.55, 0.84)			0.61 (0.53, 0.75)	0.63 (0.53, 0.73)			0.62 (0.52, 0.83)	0.58 (0.51, 0.71)			0.56 (0.52, 0.65)	0.54 (0.51, 0.85)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.066 (0.023, 0.106)	0.073 (0.035, 0.099)			0 (0, 0.062)	0 (0, 0.071)			0.018 (0, 0.096)	0.067 (0, 0.112)			0 (0, 0.071)	0 (0, 0.078)
	PARPi	count			17	17			17	17			17	17			17	17
		time			21 (10, 32)	21 (10, 32)			21 (10, 32)	21 (10, 32)			21 (10, 32)	21 (10, 32)			21 (10, 32)	21 (10, 32)
		n			23 (10, 32)	13 (3, 25)			4 (1, 11)	4 (2, 8)			4 (1, 10)	4 (1, 8)			3 (1, 9)	3 (1, 10)
		post_p			0.8 (0.72, 0.87)	0.73 (0.62, 0.89)			0.73 (0.55, 0.81)	0.7 (0.51, 0.85)			0.6 (0.54, 0.84)	0.66 (0.53, 0.78)			0.6 (0.51, 0.92)	0.71 (0.59, 0.97)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.088 (0.047, 0.104)	0.096 (0.047, 0.113)			0.029 (0, 0.05)	0.02 (0, 0.077)			0.07 (0, 0.108)	0.064 (0, 0.113)			0.023 (0, 0.061)	0.014 (0, 0.054)
HRD+	Platinum_CT	count					291	291	291	291					291	291	291	291
		time					24 (14, 34)	24 (14, 34)	24 (14, 34)	24 (14, 34)					24 (14, 34)	24 (14, 34)	24 (14, 34)	24 (14, 34)
		n					7 (3, 16)	8 (3, 17)	4 (2, 10)	4 (1, 10)					5 (2, 10)	4 (2, 9)	4 (2, 9)	4 (2, 10)
		post_p					0.8 (0.58, 0.98)	0.8 (0.59, 0.97)	0.72 (0.55, 0.91)	0.7 (0.53, 0.9)					0.72 (0.53, 0.91)	0.7 (0.53, 0.9)	0.72 (0.53, 0.91)	0.71 (0.53, 0.92)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.031 (0, 0.063)	0.034 (0, 0.062)	0.03 (0, 0.071)	0.03 (0, 0.064)					0.03 (0, 0.074)	0.03 (0, 0.071)	0.028 (0, 0.069)	0.029 (0, 0.073)
	PARPi	count					301	301	301	301					301	301	301	301
		time					23 (14, 33)	23 (14, 33)	23 (14, 33)	23 (14, 33)					23 (14, 33)	23 (14, 33)	23 (14, 33)	23 (14, 33)
		n					8 (3, 15)	8 (3, 15)	4 (1, 10)	5 (2, 9)					5 (2, 9)	4 (2, 9)	5 (2, 9)	4 (2, 9)
		post_p					0.82 (0.59, 0.96)	0.8 (0.6, 0.97)	0.7 (0.54, 0.9)	0.7 (0.54, 0.92)					0.73 (0.54, 0.9)	0.72 (0.54, 0.89)	0.72 (0.54, 0.9)	0.71 (0.53, 0.9)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.032 (0, 0.058)	0.033 (0, 0.058)	0.031 (0, 0.066)	0.029 (0, 0.069)					0.029 (0, 0.065)	0.029 (0, 0.071)	0.029 (0, 0.064)	0.027 (0, 0.071)
TEfus+	Platinum_CT	count		18		18		18		18		18		18		18		18
		time		12 (10, 20)		12 (10, 20)		12 (10, 20)		12 (10, 20)		12 (10, 20)		12 (10, 20)		12 (10, 20)		12 (10, 20)
		n		4 (3, 9)		9 (5, 14)		4 (2, 8)		2 (1, 5)		3 (2, 7)		3 (0, 6)		3 (0, 4)		3 (1, 5)
		post_p		0.63 (0.53, 0.74)		0.77 (0.63, 0.81)		0.64 (0.55, 0.8)		0.58 (0.53, 0.65)		0.63 (0.53, 0.79)		0.62 (0.55, 0.79)		0.61 (0.51, 0.79)		0.58 (0.52, 0.79)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.072 (0, 0.128)		0.061 (0.035, 0.104)		0 (0, 0.049)		0 (0, 0.071)		0.076 (0, 0.133)		0.068 (0, 0.135)		0 (0, 0.067)		0 (0, 0.069)
	PARPi	count		19		19		19		19		19		19		19		19
		time		20 (11, 30)		20 (11, 30)		20 (11, 30)		20 (11, 30)		20 (11, 30)		20 (11, 30)		20 (11, 30)		20 (11, 30)
		n		4 (3, 11)		15 (5, 23)		6 (3, 15)		3 (1, 6)		3 (2, 6)		5 (1, 8)		3 (2, 5)		2 (1, 8)
		post_p		0.73 (0.55, 0.87)		0.81 (0.67, 0.9)		0.78 (0.58, 0.92)		0.67 (0.54, 0.92)		0.57 (0.52, 0.74)		0.6 (0.51, 0.83)		0.65 (0.55, 0.83)		0.58 (0.53, 0.87)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.077 (0.026, 0.117)		0.074 (0.048, 0.099)		0.027 (0, 0.045)		0.011 (0, 0.038)		0.096 (0.038, 0.134)		0.09 (0, 0.125)		0 (0, 0.039)		0.005 (0, 0.07)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	ARSi	count	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6	6
		time	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)	22 (15, 30)
		n	26 (20, 46)	4 (0, 10)	20 (5, 30)	10 (5, 17)	6 (4, 8)	6 (2, 12)	4 (2, 8)	4 (2, 10)	8 (2, 11)	6 (1, 10)	6 (2, 8)	4 (1, 6)	4 (2, 5)	4 (2, 7)	4 (2, 8)	4 (1, 8)
		post_p	0.32 (0.18, 0.45)	0.41 (0.39, 0.47)	0.3 (0.1, 0.38)	0.34 (0.24, 0.42)	0.37 (0.08, 0.44)	0.44 (0.33, 0.48)	0.3 (0.13, 0.38)	0.38 (0.25, 0.44)	0.43 (0.34, 0.46)	0.39 (0.32, 0.42)	0.44 (0.25, 0.46)	0.34 (0.26, 0.4)	0.3 (0.24, 0.38)	0.35 (0.18, 0.45)	0.24 (0.18, 0.45)	0.34 (0.15, 0.43)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.119 (0.108, 0.137)	0.161 (0.102, 0.242)	0.139 (0.128, 0.22)	0.139 (0.114, 0.169)	0.153 (0.088, 0.215)	0.1 (0.067, 0.607)	0.152 (0.115, 0.331)	0.138 (0.094, 0.209)	0.138 (0.107, 0.184)	0.152 (0.097, 0.212)	0.127 (0.11, 0.184)	0.195 (0.141, 0.592)	0.178 (0.123, 0.207)	0.143 (0.091, 0.541)	0.204 (0.07, 1.603)	0.111 (0.102, 0.353)
	Taxane_CT	count	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7	7
		time	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)	31 (23, 34)
		n	23 (21, 48)	4 (2, 11)	29 (11, 35)	10 (5, 19)	5 (3, 10)	6 (2, 11)	2 (2, 8)	3 (1, 8)	7 (3, 11)	8 (4, 8)	7 (4, 11)	4 (1, 6)	5 (3, 10)	6 (3, 10)	4 (1, 10)	3 (1, 6)
		post_p	0.32 (0.09, 0.49)	0.4 (0.34, 0.46)	0.3 (0.18, 0.39)	0.35 (0.2, 0.44)	0.17 (0.09, 0.39)	0.3 (0.22, 0.43)	0.32 (0.23, 0.39)	0.37 (0.17, 0.41)	0.32 (0.18, 0.46)	0.24 (0.15, 0.39)	0.29 (0.16, 0.43)	0.38 (0.2, 0.49)	0.41 (0.14, 0.49)	0.35 (0.3, 0.45)	0.36 (0.28, 0.47)	0.44 (0.29, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.131 (0.112, 0.164)	0.146 (0.09, 0.366)	0.139 (0.119, 0.151)	0.154 (0.109, 0.179)	0.162 (0.1, 0.186)	0.122 (0.077, 0.216)	0.181 (0.136, 0.543)	0.157 (0.106, 0.496)	0.155 (0.107, 0.468)	0.169 (0.113, 0.347)	0.128 (0.084, 0.154)	0.26 (0.118, 0.445)	0.113 (0.082, 0.301)	0.099 (0.084, 0.21)	0.133 (0.095, 1.155)	0.094 (0.077, 0.148)
TP53- & AR-	ARSi	count	247	247			247	247
		time	16 (9, 30)	16 (9, 30)			16 (9, 30)	16 (9, 30)
		n	24 (15, 53)	5 (2, 12)			5 (2, 11)	5 (2, 11)
		post_p	0.33 (0.13, 0.47)	0.42 (0.22, 0.49)			0.37 (0.15, 0.47)	0.38 (0.15, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.126 (0.103, 0.171)	0.146 (0.094, 0.282)			0.13 (0.077, 0.259)	0.128 (0.075, 0.33)
	Taxane_CT	count	233	233			233	233
		time	14 (10, 28)	14 (10, 28)			14 (10, 28)	14 (10, 28)
		n	23 (15, 50)	5 (2, 11)			5 (2, 11)	5 (2, 10)
		post_p	0.3 (0.11, 0.46)	0.41 (0.23, 0.48)			0.4 (0.15, 0.47)	0.4 (0.22, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.128 (0.105, 0.174)	0.158 (0.101, 0.29)			0.135 (0.075, 0.272)	0.133 (0.074, 0.311)
	Platinum_CT	count	22	22			22	22
		time	12 (8, 17)	12 (8, 17)			12 (8, 17)	12 (8, 17)
		n	18 (14, 26)	4 (0, 6)			4 (1, 7)	4 (2, 8)
		post_p	0.25 (0.13, 0.42)	0.37 (0.16, 0.47)			0.46 (0.38, 0.5)	0.4 (0.3, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.141 (0.114, 0.172)	0.208 (0.094, 0.474)			0.085 (0.003, 0.166)	0.113 (0.064, 0.21)
	PARPi	count	18	18			18	18
		time	12 (9, 19)	12 (9, 19)			12 (9, 19)	12 (9, 19)
		n	19 (14, 33)	5 (3, 7)			4 (1, 7)	4 (1, 9)
		post_p	0.31 (0.13, 0.41)	0.39 (0.25, 0.47)			0.45 (0.43, 0.5)	0.43 (0.36, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.147 (0.115, 0.196)	0.183 (0.108, 0.34)			0.117 (0.066, 0.202)	0.123 (0.082, 0.358)
TP53+	ARSi	count			74	74			74	74			74	74			74	74
		time			18 (8, 32)	18 (8, 32)			18 (8, 32)	18 (8, 32)			18 (8, 32)	18 (8, 32)			18 (8, 32)	18 (8, 32)
		n			16 (8, 32)	10 (5, 23)			4 (1, 8)	3 (1, 7)			5 (1, 9)	4 (0, 9)			3 (1, 7)	3 (1, 7)
		post_p			0.34 (0.15, 0.48)	0.37 (0.14, 0.47)			0.37 (0.25, 0.48)	0.39 (0.21, 0.48)			0.41 (0.23, 0.49)	0.41 (0.27, 0.49)			0.41 (0.25, 0.48)	0.4 (0.22, 0.49)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.138 (0.097, 0.179)	0.14 (0.102, 0.235)			0.133 (0.079, 0.366)	0.14 (0.077, 0.484)			0.147 (0.09, 0.291)	0.16 (0.101, 0.448)			0.142 (0.078, 0.317)	0.126 (0.071, 0.397)
	Taxane_CT	count			74	74			74	74			74	74			74	74
		time			20 (10, 33)	20 (10, 33)			20 (10, 33)	20 (10, 33)			20 (10, 33)	20 (10, 33)			20 (10, 33)	20 (10, 33)
		n			20 (9, 34)	12 (5, 23)			4 (1, 8)	3 (1, 9)			5 (2, 11)	5 (1, 10)			4 (1, 8)	4 (1, 8)
		post_p			0.33 (0.08, 0.48)	0.34 (0.18, 0.48)			0.38 (0.21, 0.48)	0.4 (0.19, 0.46)			0.36 (0.2, 0.48)	0.4 (0.23, 0.48)			0.37 (0.24, 0.46)	0.4 (0.19, 0.48)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.134 (0.103, 0.191)	0.132 (0.105, 0.215)			0.148 (0.079, 0.348)	0.131 (0.069, 0.43)			0.167 (0.11, 0.313)	0.157 (0.102, 0.356)			0.133 (0.068, 0.291)	0.129 (0.076, 0.225)
	Platinum_CT	count			3	3			3	3			3	3			3	3
		time			12 (9, 17)	12 (9, 17)			12 (9, 17)	12 (9, 17)			12 (9, 17)	12 (9, 17)			12 (9, 17)	12 (9, 17)
		n			11 (10, 14)	7 (4, 13)			3 (1, 5)	3 (1, 5)			2 (1, 4)	3 (1, 3)			2 (1, 2)	0 (0, 3)
		post_p			0.36 (0.19, 0.44)	0.16 (0.11, 0.43)			0.46 (0.45, 0.48)	0.44 (0.38, 0.47)			0.46 (0.38, 0.49)	0.39 (0.34, 0.46)			0.42 (0.4, 0.42)	0.49 (0.49, 0.49)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.166 (0.14, 0.209)	0.205 (0.086, 0.274)			0.116 (0.062, 0.177)	0.075 (0.069, 0.707)			0.182 (0.036, 0.21)	0.297 (0.242, 0.412)			0.202 (0.105, 4.715)	0.242 (0.242, 0.242)
	PARPi	count			2	2			2	2			2	2			2	2
		time			12 (7, 16)	12 (7, 16)			12 (7, 16)	12 (7, 16)			12 (7, 16)	12 (7, 16)			12 (7, 16)	12 (7, 16)
		n			12 (9, 16)	8 (6, 10)			0 (0, 1)	4 (3, 5)			4 (3, 5)	2 (1, 2)			2 (0, 3)	2 (1, 3)
		post_p			0.3 (0.25, 0.34)	0.35 (0.27, 0.43)			0.48 (0.48, 0.48)	0.49 (0.49, 0.5)			0.43 (0.42, 0.43)	0.46 (0.43, 0.48)			0.46 (0.46, 0.46)	0.42 (0.38, 0.45)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.142 (0.137, 0.147)	0.132 (0.117, 0.147)			0 (0, 0)	0.084 (0.06, 0.108)			0.202 (0.13, 0.273)	0.392 (0.161, 0.622)			0.076 (0.076, 0.076)	0.165 (0.099, 0.231)
HRD+	ARSi	count					214	214	214	214					214	214	214	214
		time					21 (14, 32)	21 (14, 32)	21 (14, 32)	21 (14, 32)					21 (14, 32)	21 (14, 32)	21 (14, 32)	21 (14, 32)
		n					6 (2, 12)	6 (3, 12)	4 (1, 8)	4 (1, 8)					5 (2, 9)	4 (2, 8)	4 (2, 8)	4 (2, 8)
		post_p					0.33 (0.13, 0.47)	0.34 (0.14, 0.47)	0.37 (0.18, 0.48)	0.39 (0.21, 0.48)					0.36 (0.17, 0.48)	0.38 (0.18, 0.46)	0.38 (0.18, 0.48)	0.4 (0.21, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.122 (0.081, 0.241)	0.127 (0.078, 0.258)	0.144 (0.075, 0.357)	0.139 (0.071, 0.314)					0.136 (0.073, 0.382)	0.153 (0.073, 0.312)	0.13 (0.073, 0.324)	0.136 (0.076, 0.305)
	Taxane_CT	count					197	197	197	197					197	197	197	197
		time					22 (16, 32)	22 (16, 32)	22 (16, 32)	22 (16, 32)					22 (16, 32)	22 (16, 32)	22 (16, 32)	22 (16, 32)
		n					6 (3, 13)	6 (3, 12)	5 (2, 9)	5 (2, 9)					5 (2, 9)	4 (2, 9)	5 (2, 9)	4 (2, 8)
		post_p					0.33 (0.1, 0.46)	0.32 (0.13, 0.47)	0.36 (0.18, 0.48)	0.38 (0.2, 0.48)					0.38 (0.19, 0.47)	0.38 (0.17, 0.48)	0.37 (0.18, 0.46)	0.37 (0.16, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.123 (0.079, 0.229)	0.124 (0.078, 0.272)	0.137 (0.078, 0.269)	0.135 (0.076, 0.288)					0.125 (0.074, 0.343)	0.133 (0.077, 0.313)	0.133 (0.084, 0.294)	0.125 (0.078, 0.328)
TEfus+	ARSi	count		65		65		65		65		65		65		65		65
		time		21 (12, 34)		21 (12, 34)		21 (12, 34)		21 (12, 34)		21 (12, 34)		21 (12, 34)		21 (12, 34)		21 (12, 34)
		n		5 (2, 12)		13 (7, 23)		5 (2, 12)		3 (1, 8)		6 (3, 10)		5 (1, 11)		4 (1, 7)		4 (1, 8)
		post_p		0.36 (0.18, 0.48)		0.34 (0.15, 0.47)		0.33 (0.12, 0.44)		0.38 (0.19, 0.46)		0.41 (0.15, 0.49)		0.39 (0.22, 0.48)		0.34 (0.12, 0.48)		0.42 (0.23, 0.49)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.163 (0.103, 0.309)		0.137 (0.103, 0.205)		0.134 (0.079, 0.292)		0.13 (0.081, 0.286)		0.145 (0.1, 0.32)		0.153 (0.095, 0.257)		0.172 (0.073, 0.481)		0.119 (0.074, 0.255)
	Taxane_CT	count		67		67		67		67		67		67		67		67
		time		22 (13, 31)		22 (13, 31)		22 (13, 31)		22 (13, 31)		22 (13, 31)		22 (13, 31)		22 (13, 31)		22 (13, 31)
		n		5 (2, 12)		13 (8, 22)		6 (2, 10)		4 (1, 8)		5 (2, 9)		5 (2, 8)		4 (1, 7)		4 (2, 8)
		post_p		0.37 (0.19, 0.5)		0.35 (0.1, 0.47)		0.31 (0.16, 0.47)		0.38 (0.14, 0.47)		0.42 (0.2, 0.48)		0.41 (0.16, 0.49)		0.38 (0.2, 0.48)		0.38 (0.17, 0.48)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.152 (0.098, 0.296)		0.138 (0.102, 0.194)		0.135 (0.078, 0.342)		0.138 (0.068, 0.465)		0.15 (0.097, 0.329)		0.157 (0.095, 0.361)		0.117 (0.063, 0.246)		0.119 (0.074, 0.287)
	PARPi	count		1		1		1		1		1		1		1		1
		time		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)		15 (15, 15)
		n		1 (1, 1)		6 (6, 6)		0 (0, 0)		3 (3, 3)		6 (6, 6)		5 (5, 5)		1 (1, 1)		3 (3, 3)
		post_p		0.46 (0.46, 0.46)		0.48 (0.48, 0.48)		NA (NA, NA)		0.4 (0.4, 0.4)		0.17 (0.17, 0.17)		0.13 (0.13, 0.13)		0.37 (0.37, 0.37)		0.48 (0.48, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.151 (0.151, 0.151)		0.118 (0.118, 0.118)		NA (NA, NA)		0.151 (0.151, 0.151)		0.223 (0.223, 0.223)		0.361 (0.361, 0.361)		13.589 (13.589, 13.589)		0.041 (0.041, 0.041)